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Abstract: Interstitial lung disease (ILD) constitutes the most critical comorbidity in autoimmune diseases (ADs) and its early diagnosis remains a challenge for clinicians. Accordingly, we evaluated whether E-selectin, ICAM-1, and ET-1, key molecules in endothelial damage, could be useful biomarkers for the detection of AD-ILD+. We recruited patients with rheumatoid arthritis (RA)-ILD+ (n = 21) and systemic sclerosis (SSc)-ILD+ (n = 21). We included comparison groups of patients: RA-ILD? (n = 25), SSc-ILD? (n = 20), and idiopathic pulmonary fibrosis (IPF) (n = 21). Serum levels of these proteins were determined by ELISA. E-selectin, ICAM-1, and ET-1 serum levels were increased in RA-ILD+ and IPF patients in comparison to RA-ILD? patients. Additionally, SSc-ILD+ and IPF patients exhibited higher ICAM-1 levels than those with SSc-ILD?. The ability of E-selectin, ICAM-1, and ET-1 to discriminate RA-ILD+ from RA-ILD? patients, and ICAM-1 to distinguish SSc-ILD+ from SSc-ILD? patients was confirmed using ROC curve analysis. Furthermore, elevated levels of ET-1 and E-selectin correlated with lung function decline in RA-ILD+ and SSc-ILD+ patients, respectively. In conclusion, our findings support the relevant role of E-selectin, ICAM-1, and ET-1 in RA-ILD+ patients as well as of ICAM-1 in SSc-ILD+ patients, constituting potential screening blood biomarkers of ILD in AD. Moreover, this study suggests ET-1 and E-selectin as possible indicators of worsening lung function in RA-ILD+ and SSc-ILD+ patients, respectively
Fuente: International journal of molecular sciences, 2023, 24(15), 12518
Año de publicación: 2023
Nº de páginas: 12
Tipo de publicación: Artículo de Revista
Url de la publicación: https://
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BELÉN ATIENZA MATEO
MORA-CUESTA, VÍCTOR M.
MORA-GIL, MARÍA SEBASTIÁN
RICARDO BLANCO ALONSO
JOSE MANUEL CIFRIAN MARTINEZ
MIGUEL ANGEL GONZALEZ-GAY MANTECON