Abstract: The TGF superfamily is composed of more than 33 growth and differentiation factors,
including TGF1, 2, 3, BMPs, GDFs, nodal-related proteins, and activins. These members usually
exert pleiotropic actions on several tissues and control multiple cellular processes, such as cell
growth, cell survival, cell migration, cell fate specification, and differentiation, both during embryonic
development and postnatal life. Although the effects of these factors on immune responses were
elucidated long ago, most studies have been focused on the actions of TGFs on T cells, as major
regulators of adaptive immunity. In this review, we discuss new findings about the involvement of
TGF superfamily members in the control of B cell development and function. Moreover, the potential
contribution of TGF signaling to control B cell-mediated autoimmune diseases and its utility in the
design of new therapies are also discussed.
Fuente: Int. J. Mol. Sci. Volume 19, Issue 12, December 2018, Article number 3928
Editorial: MDPI
Fecha de publicación: 01/12/2018
Nº de páginas: 18
Tipo de publicación: Artículo de Revista
DOI: 10.3390/ijms19123928
ISSN: 1661-6596,1422-0067
Proyecto español: SAF2017-82905-R
Url de la publicación: https://dx.doi.org/10.3390/ijms19123928