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TOR Complex 1: Orchestrating nutrient signaling and cell cycle progression

Abstract: The highly conserved TOR signaling pathway is crucial for coordinating cellular growth with the cell cycle machinery in eukaryotes. One of the two TOR complexes in budding yeast, TORC1, integrates environmental cues and promotes cell growth. While cells grow, they need to copy their chromosomes, segregate them in mitosis, divide all their components during cytokinesis, and finally physically separate mother and daughter cells to start a new cell cycle apart from each other. To maintain cell size homeostasis and chromosome stability, it is crucial that mechanisms that control growth are connected and coordinated with the cell cycle. Successive periods of high and low TORC1 activity would participate in the adequate cell cycle progression. Here, we review the known molecular mechanisms through which TORC1 regulates the cell cycle in the budding yeast Saccharomyces cerevisiae that have been extensively used as a model organism to understand the role of its mammalian ortholog, mTORC1

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Foltman M., Sanchez-Diaz A.,

 Fuente: International Journal of Molecular Sciences, 2023, 24, 15745

Editorial: MDPI

 Año de publicación: 2023

Nº de páginas: 22

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/ijms242115745

ISSN: 1661-6596,1422-0067

 Proyecto español: PID2019-106745GB-I00