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 Detalle_Publicacion

Metallomic signatures of lung cancer and chronic obstructive pulmonary disease

Abstract: Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: International Journal of Molecular Sciences, 2023, 24, 14250

Editorial: MDPI

 Año de publicación: 2023

Nº de páginas: 14

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/ijms241814250

ISSN: 1661-6596,1422-0067

Autoría

CALLEJÓN-LECLIC, BELÉN

SÁNCHEZ ESPIRILLA, SAIDA

GOTERA-RIVERA, CAROLINA

SANTANA, RAFAEL

DÍAZ-OLIVARES, ISABEL

MARÍN, JOSÉ M.

CASANOVA MACARIO, CIRO

GARCÍA COSÍO, BORJA

FUSTER, ANTONIA

SOLANES GARCÍA, INGRID

TORRES, JUAN P. DE

FEU COLLADO, NURIA

CABRERA LÓPEZ, CARLOS

ROMERO PLAZA, AMPARO

PADRÓN FRAYSSE, LUIS ALEJANDRO

MÁRQUEZ MARTÍN, EDUARDO

MARÍN ROYO, MARGARITA

BALCELLS VILARNAU, EVA

LLUNELL CASANOVAS, ANTONIA