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Yoghurt intake and gastric cancer: a pooled analysis of 16 studies of the StoP Consortium

Abstract: Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94-1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88?0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85-0.99) and 0.78 (95% CI = 0.73-0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91-1.02) for cardia, 1.03 (95% CI = 1.00-1.07) for non-cardia, 1.12 (95% CI = 1.07-1.19) for diffuse and 1.02 (95% CI = 0.97-1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Collatuzzo G., Negri E., Pelucchi C., Bonzi R., Turati F., Rabkin C.S., Liao L.M., Sinha R., Palli D., Ferraroni M., López-Carrillo L., Lunet N., Morais S., Albanes D., Weinstein S.J., Parisi D., Zaridze D., Maximovitch D., Dierssen-Sotos T., Jiménez-Moleón J.J., Vioque J., Garcia de la Hera M., Curado M.P., Dias-Neto E., Hernández-Ramírez R.U., López-Cervantes M., Ward M.H., Tsugane S., Hidaka A., Lagiou A., Lagiou P., Zhang Z.F.,

 Fuente: Nutrients, 2023, 15(8), 1877

Editorial: MPDI

 Año de publicación: 2023

Nº de páginas: 13

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/nu15081877

ISSN: 2072-6643

Url de la publicación: https://doi.org/10.3390/ nu15081877

Autores/as

COLLATUZZO, GIULIA

NEGRI, EVA

PELUCCHI, CLAUDIO

BONZI, ROSSELLA

TURATI, FEDERICA

RABKIN, CHARLES S.

LIAO, LINDA M.

SINHA, RASHMI

PALLI, DOMENICO

FERRARONI, MONICA

LÓPEZ-CARRILLO, LIZBETH

LUNET, NUNO

MORAIS, SAMANTHA

ALBANES, DEMETRIUS

WEINSTEIN, STEPHANIE J.

PARISI, DOMINICK

ZARIDZE, DAVID

MAXIMOVITCH, DMITRY

JIMÉNEZ-MOLEÓN, JOSÉ JUAN