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Germline variation at 8q24 and prostate cancer risk in men of european ancestry

Abstract: Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p?

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Autoría: Matejcic M., Saunders E.J., Dadaev T., Brook M.N., Wang K., Sheng X., Olama A.A.A., Schumacher F.R., Ingles S.A., Govindasami K., Benlloch S., Berndt S.I., Albanes D., Koutros S., Muir K., Stevens V.L., Gapstur S.M., Tangen C.M., Batra J., Clements J., Gronberg H., Pashayan N., Schleutker J., Wolk A., West C., Mucci L., Kraft P., Cancel-Tassin G., Sorensen K.D., Maehle L., Grindedal E.M., Strom S.S., Neal D.E., Hamdy F.C., Donov

Fuente: Nature Communications, 2018, 9(1), 4616

Editorial: Nature Publishing Group

Año de publicación: 2018

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

DOI: 10.1038/s41467-018-06863-1

ISSN: 2041-1723

Url de la publicación: https://dx.doi.org/10.1038/s41467-018-06863-1

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