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Abstract: Acinetobacter baumannii is a Gram negative nosocomial pathogen that has acquired increasing worldwide notoriety due to its high antibiotic resistance range and mortality rates in hospitalized patients. Therefore, it is necessary to better understand key aspects of A. baumannii pathogenesis such as host-pathogen interactions. In this report, we analyzed both gene expression and cytokine production by human neutrophils infected with A. baumannii. Our assays reveal a proinflammatory response of neutrophils after A. baumannii infection, since intracellular transcription of effector proteins such as COX-2, transcription factors, and proinflammatory cytokines resulted significantly upregulated in neutrophils infected by A. baumannii, compared with unstimulated human neutrophils. Translation and release of CXCL-8, IL-1? and TNF-? by neutrophils was confirmed by protein quantification in culture supernatants. Results obtained in this report reinforce the importance of human neutrophils in controlling A. baumannii infections but also emphasize the proinflammatory nature of these host-pathogen interactions as a target for future immunomodulatory therapies.
Fuente: PLoS ONE 15(11): e0242674
Publisher: Public Library of Science
Publication date: 30/11/2020
No. of pages: 10
Publication type: Article
DOI: 10.1371/journal.pone.0242674
ISSN: 1932-6203
Publication Url: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0242674
Consult in UCrea Read publication
LÁZARO DÍEZ, MARÍA
CHAPARTEGUI GONZÁLEZ, ITZIAR
SUBERBIOLA, BORJA
J. GONZALO OCEJOVINYALS
MARCOS LOPEZ HOYOS
RAMOS VIVAS, JOSÉ
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