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Abstract: Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance in human pathogens. This dissemination could be controlled by molecules that interfere with the conjugation process. A search for conjugation inhibitors among a collection of 1,632 natural compounds, identified tanzawaic acids A and B as best hits. They specially inhibited IncW and IncFII conjugative systems, including plasmids mobilized by them. Plasmids belonging to IncFI, IncI, IncL/M, IncX and IncH incompatibility groups were targeted to a lesser extent, whereas IncN and IncP plasmids were unaffected. Tanzawaic acids showed reduced toxicity in bacterial, fungal or human cells, when compared to synthetic conjugation inhibitors, opening the possibility of their deployment in complex environments, including natural settings relevant for antibiotic resistance dissemination.
Fuente: PLoS One, 2016, 11(1), e0148098
Publisher: Public Library of Science
Year of publication: 2016
No. of pages: 13
Publication type: Article
DOI: 10.1371/journal.pone.0148098
ISSN: 1932-6203
Spanish project: BFU2014-55534-C2-1-P
Publication Url: https://www.doi.org/10.1371/journal.pone.0148098
Consult in UCrea Read publication
MARIA GETINO REDONDO
RAUL FERNANDEZ LOPEZ
CAROLINA PALENCIA GANDARA
JAVIER CAMPOS GOMEZ
SÁNCHEZ-LÓPEZ, JOSE M.
MARTÍNEZ, MARTA
FERNÁNDEZ, ANTONIO
FERNANDO DE LA CRUZ CALAHORRA
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