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Mice deficient in CD38 develop an attenuated form of collagen type II-induced arthritis

Abstract: CD38, a type II transmembrane glycoprotein expressed in many cells of the immune system, is involved in cell signaling, migration and differentiation. Studies in CD38 deficient mice (CD38 KO mice) indicate that this molecule controls inflammatory immune responses, although its involvement in these responses depends on the disease model analyzed. Here, we explored the role of CD38 in the control of autoimmune responses using chicken collagen type II (col II) immunized C57BL/6-CD38 KO mice as a model of collagen-induced arthritis (CIA). We demonstrate that CD38 KO mice develop an attenuated CIA that is accompanied by a limited joint induction of IL-1? and IL-6 expression, by the lack of induction of IFN? expression in the joints and by a reduction in the percentages of invariant NKT (iNKT) cells in the spleen. Immunized CD38 KO mice produce high levels of circulating IgG1 and low of IgG2a anti-col II antibodies in association with reduced percentages of Th1 cells in the draining lymph nodes. Altogether, our results show that CD38 participates in the pathogenesis of CIA controlling the number of iNKT cells and promoting Th1 inflammatory responses. © 2012 Postigo et al.

 Authorship: Postigo J., Iglesias M., Cerezo-Wallis D., Rosal-Vela A., García-Rodríguez S., Zubiaur M., Sancho J., Merino R., Merino J.,

 Fuente: PLoS One, 2012, 7(3), e33534

 Publisher: PloS ONE

 Year of publication: 2012

 No. of pages: 9

 Publication type: Article

 DOI: 10.1371/journal.pone.0033534

 ISSN: 1932-6203

 Spanish project: SAF2008-02042

Authorship

JORGE POSTIGO FERNANDEZ

MARCOS IGLESIAS LOZANO

CEREZO-WALLIS, DANIELA

ROSAL-VELA, ANTONIO

GARCÍA RODRÍGUEZ, SONIA

ZUBIAUR, MERCEDES

SANCHO, JAIME