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Abstract: The decrease of volume estimates in different structures of the medial temporal lobe related to memory correlate with the decline of cognitive functions in neurodegenerative diseases. This study presents data on the association between MRI quantitative parameters of medial temporal lobe structures and their quantitative estimate in microscopic examination. Twelve control cases had ex-vivo MRI, and thereafter, the temporal lobe of both hemispheres was sectioned from the pole as far as the level of the splenium of the corpus callosum. Nissl stain was used to establish anatomical boundaries between structures in the medial temporal lobe. The study included morphometrical and stereological estimates of the amygdaloid complex, hippocampus, and temporal horn of the lateral ventricle, as well as different regions of grey and white matter in the temporal lobe. Data showed a close association between morphometric MRI images values and those based on the histological determination of boundaries. Only values in perimeter and circularity of the piamater were different. This correspondence is also revealed by the stereological study, although irregular compartments resulted in a lesser agreement. Neither age (< 65 yr and > 65yr) nor hemisphere had any effect. Our results indicate that ex-vivo MRI is highly associated with quantitative information gathered by histological examination, and these data could be used as structural MRI biomarker in neurodegenerative diseases.
Fuente: PLoS ONE, 2015, 10(6): e0130314
Publisher: Public Library of Science
Publication date: 22/06/2015
No. of pages: 16
Publication type: Article
DOI: 10.1371/journal.pone.0130314
ISSN: 1932-6203
Spanish project: BFU-2009-14705
Consult in UCrea Read publication
DELGADO-GONZÁLEZ, JOSÉ CARLOS
MANSILLA-LEGORBURO, FRANCISCO
FLORENSA-VILA, JOSÉ
INSAUSTI, ANA MARÍA
VIÑUELA, ANTONIO
TUÑÓN-ÁLVAREZ, TERESA
MARCOS CRUZ RODRIGUEZ
MOHEDANO-MORIANO, ALICIA
INSAUSTI, RICARDO
ARTACHO-PÉRULA, EMILIO
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