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61 results

1 of 3

High rate of mutations of adhesion molecules and extracellular matrix glycoproteins in patients with adult-onset focal and segmental glomerulosclerosis

Article

Biomedicines, 2023, 11, 1764

Authorship: SARA MARCOS GONZALEZ, EMILIO RODRIGO CALABIA, IGNACIO VARELA EGOCHEAGA, MICHAL CERVIENKA, JAVIER FREIRE SALINAS, JOSE JAVIER GOMEZ ROMAN

2023

MYC directly transactivates CR2/CD21, the receptor of the Epstein-Barr virus, enhancing the viral infection of Burkitt lymphoma cells

Article

Oncogene, 2023, 42(45), 3358-3370

Authorship: ESTER MOLINA HOYO, LUCIA GARCIA GUTIERREZ, VANESSA JUNCO RUISÁNCHEZ, MERCEDES PÉREZ-OLIVARES, VIRGINA G. DE YÉBENES, ROSA FERNANDA BLANCO FERNÁNDEZ, LAURA QUEVEDO PALACIO, JUAN CARLOS ACOSTA COBACHO, ANA V. MARÍN, DANIELA ULGIATI, RAMON MERINO PEREZ, MARIA DOLORES DELGADO VILLAR, IGNACIO VARELA EGOCHEAGA, JOSÉ R. REGUEIRO, IGNACIO MORENO DE ALBORAN, ALMUDENA R. RAMIRO, JAVIER LEON SERRANO

2023

PLCy1/PKC0 Downstream Signaling Controls Cutaneous T-Cell Lymphoma Development and Progression

Article

J Invest Dermatol . 2022 May;142(5):1391-1400.e15

Authorship: NURIA GARCIA DIAZ, BERTA CASAR MARTINEZ, RUTH ALONSO-ALONSO, LAURA QUEVEDO PALACIO, MARTA RODRÍGUEZ, FULGENCIO RUSO JULVE, ANNA ESTEVE-CODINA, MARTA GUT, ALEJANDRO A. GRU, MARIA CARMEN GONZALEZ VELA, IVO GUT, JOSÉ LUIS RODRIGUEZ-PERALTO, IGNACIO VARELA EGOCHEAGA, PABLO LUIS ORTIZ-ROMERO, MIGUEL A. PIRIS, JOSE PEDRO VAQUE DIEZ

2022

Role of SWI/SNF chromatin remodeling genes in lung cancer development

Article

Biochemical Society transactions, 2022, 50(3), 1143-1150

Authorship: BEATRIZ MONTERDE MARTINEZ, IGNACIO VARELA EGOCHEAGA

2022

The HDAC7-TET2 epigenetic axis is essential during early B lymphocyte development

Article

Nucleic Acids Research, 2022, Vol. 50, No. 15 8471-8490

Authorship: ALBA AZAGRA, AINARA MELER, ORIOL DE BARRIOS, LAUREANO TOMÁS-DAZA, OLGA COLLAZO, BEATRIZ MONTERDE MARTINEZ, MIREIA OBIOLS, LLORENÇ ROVIROSA, MARÍA VILA-CASADESÚS, MÓNICA CABRERA-PASADAS, MAR GUSI-VIVES, THOMAS GRAF, IGNACIO VARELA EGOCHEAGA, JOSÉ LUIS SARDINA, BIOLA M. JAVIERRE, MARIBEL PARRA

29/07/2022

pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation

Article

Nature Communications (2022) 13: 6840

Authorship: OLGA BOIX, MARION MARTÍNEZ, SANTIAGO VIDAL, MARTA GIMÉNEZ-ALEJANDRE, LLUÍS PALENZUELA, LAURA LORENZO-SANZ, LAURA QUEVEDO PALACIO, OLIVIER MOSCOSO, JORGE RUIZ-ORERA, PILAR XIMÉNEZ-EMBÚN, NIKAOLY CIRIACO, PAOLO NUCIFORO, CAMILLE STEPHAN-OTTO ATTOLILNI, M. MAR ALBÀ, JAVIER MUÑOZ, TIAN V. VIAN, IGNACIO VARELA EGOCHEAGA, ANA VIVANCOS, SANTIAGO RAMÓN Y CAJAL, PURIFICACIÓN MUÑOZ

11/11/2022

ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer

Article

Oncogene 2021 Apr;40(16):2923-2935

Authorship: THAIDY MORENO RODRIGUEZ, BEATRIZ MONTERDE MARTINEZ, LAURA GONZALEZ SILVA, ISABEL BETANCOR-FERNÁNDEZ, CARLOS REVILLA GOMEZ, ANTONIO MANUEL AGRAZ DOBLAS, JAVIER FREIRE, PABLO ISIDRO, LAURA QUEVEDO PALACIO, ROSA FERNANDA BLANCO FERNÁNDEZ, SANTIAGO MONTES-MORENO, LAURA CERECEDA, AURORA ASTUDILLO, BERTA CASAR MARTINEZ, PEDRO CRESPO BARAJA, CRISTINA MORALES TORRES, PAOLA SCAFFIDI, JAVIER GÓMEZ-ROMÁN, EDUARDO SALIDO, IGNACIO VARELA EGOCHEAGA

2021

Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLLrearranged B cell acute lymphoblastic leukemia

Article

J Clin Invest . 2021 Jul 1;131(13):e138833

Authorship: JUAN RAMÓN TEJEDOR, CLARA BUENO, MERITXELL VINYOLES, PAOLO PETAZZI, ANTONIO MANUEL AGRAZ DOBLAS, ISABEL COBO, RAÚL TORRES-RUIZ, GUSTAVO F. BAYÓN, RAÚL F. PÉREZ, SARA LÓPEZ- TAMARGO, FRANCISCO GUTIERREZ-AGÜERA, PABLO SANTAMARINA-OJEDA, MANUEL RAMÍREZ- ORELLANA, MICHELA BARDINI, GIANNI CAZZANIGA, PAOLA BALLERINI, PAULINE SCHNEIDER, RONALD W. STAM, IGNACIO VARELA EGOCHEAGA, MARIO F. FRAGA

2021

A Spotlight on cancer researchers in Spain: new paradigms and disruptive ideas

Article

Clinical and Translational Oncology, 2020, 22(6), 798-801

Authorship: S. RAMÓN Y CAJAL, P. SANCHO, L. SOUCEK, H. PEINADO, M. ABAD, M. VALIENTE, A. EFEYAN, J. PARDO, V. QUESADA, J. JIMENO, P. M. DUQUE, A. ANTÓN, IGNACIO VARELA EGOCHEAGA, A. J. SCHUHMACHER

2020

The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells

Article

Journal of Biological Chemistry, 2020, 295(7), 2001-2017

Authorship: MARIA DEL CARMEN LAFITA NAVARRO, JUDIT LIAÑO PONS, ANDREA QUINTANILLA CAVIA, IGNACIO VARELA EGOCHEAGA, ROSA FERNANDA BLANCO FERNÁNDEZ, FABIANA OURIQUE DA SILVA, GABRIEL BRETONES SANCHEZ, JULIA ARESTI, ESTER MOLINA HOYO, PATRICK CARROLL, PETER HURLIN, OCTAVIO A. ROMERO, MONTSE SÁNCHEZ-CÉSPEDES, ROBERT N. EISENMAN, MARIA DOLORES DELGADO VILLAR, JAVIER LEON SERRANO

09/01/2020

Analysis pipelines for cancer genome sequencing in mice

Article

Nat Protoc . 2020 Feb;15(2):266-315.

Authorship: SEBASTIAN LANGE, THOMAS ENGLEITNER, SEBASTIAN MUELLER, ROMAN MARESCH, MAXIMILIAN ZWIEBEL, LAURA GONZALEZ SILVA, GÜNTER SCHNEIDER, RUBY BANERJEE, FENGTANG YANG, GEORGE S. VASSILIOU, MATHIAS J. FRIEDRICH, DIETER SAUR, IGNACIO VARELA EGOCHEAGA, ROLAND RAD

01/02/2020

Tumor Functional Heterogeneity Unraveled by scRNA-seq Technologies

Article

Trends Cancer . 2020 Jan;6(1):13-19

Authorship: LAURA GONZALEZ SILVA, LAURA QUEVEDO PALACIO, IGNACIO VARELA EGOCHEAGA

2020

Bone Marrow Clonogenic Myeloid Progenitors from NPM1-Mutated AML Patients Do Not Harbor the NPM1 Mutation: Implication for the Cell-Of-Origin of NPM1+ AML

Article

Genes (Basel) . 2020 Jan 9;11(1):73

Authorship: RAFAEL DIAZ DE LA GUARDIA, LAURA GONZALEZ SILVA, BELÉN LÓPEZ MILLÁN, JUAN JOSÉ RODRÍGUEZ SEVILLA, MATTEO L. BARONI, CLARA BUENO, EDUARDO ANGUITA, SUSANA VIVES, LAURA PALOMO, HELENE LAPILLONNE, IGNACIO VARELA EGOCHEAGA, PABLO MENÉNDEZ

09/01/2020

HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia

Article

Leukemia . 2020 Dec 1.

Authorship: ORIOL DE BARRIOS, ALEXANDROS GALARAS, JUAN L. TRINCADO, ALBA AZAGRA, OLGA COLLAZO, AINARA MELER, ANTONIO MANUEL AGRAZ DOBLAS, CLARA BUENO, PAOLA BALLERINI, GIOVANNI CAZZANIGA, RONALD W. STAM, IGNACIO VARELA EGOCHEAGA, PAOLA DE LORENZO, MARIA GRAZIA VALSECCHI, PANTELIS HATZIS, PABLO MENÉNDEZ, MARIBEL PARRA

2020

Enhanced Hemato-Endothelial Specification During Human Embryonic Differentiation Through Developmental Cooperation Between AF4-MLL and MLL-AF4 Fusions

Article

Haematologica, 104 (6), 1189-1201 Jun 2019

Authorship: CLARA BUENO, FERNANDO J. CALERO-NIETO, XIAONAN WANG, RAFAEL VALDÉS-MAS, FRANCISCO GUTIÉRREZ-AGÜERA, HELEIA ROCA-HO, VERONICA AYLLON, PEDRO J. REAL, DAVID ARAMBILET, LLUIS ESPINOSA, RAUL TORRES-RUIZ, ANTONIO AGRAZ DOBLAS, IGNACIO VARELA EGOCHEAGA, JASPER DE BOER, ANNA BIGAS, BERTIE GOTTGENS, ROLF MARSCHALEK, PABLO MENENDEZ

2019

CD133-directed CAR T-cells for MLL Leukemia: On-Target, Off-Tumor Myeloablative Toxicity

Article

Leukemia, 33 (8), 2090-2125 Aug 2019

Authorship: CLARA BUENO, TALIA VELASCO-HERNANDEZ, FRANCISCO GUTIÉRREZ-AGÜERA, SAMANTA ROMINA ZANETTI, MATTEO L. BARONI, DIEGO SÁNCHEZ-MARTÍNEZ, OSCAR MOLINA, ADRIA CLOSA, ANTONIO AGRAZ-DOBLÁS, PEDRO MARÍN, EDUARDO EYRAS, IGNACIO VARELA EGOCHEAGA, PABLO MENÉNDEZ

2019

Natural history and cell of origin of TC F3- ZN F384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL

Article

Blood, 2019, 134(11), 900-905

Authorship: CLARA BUENO, J RAMÓN TEJEDOR, RACHAEL BASHFORD-ROGERS, LAURA GONZALEZ SILVA, RAFAEL VALDÉS-MAS, ANTONIO AGRAZ-DOBLÁS, RAFAEL DÍAZ DE LA GUARDIA, JORDI RIBERA, LURDES ZAMORA, CHRYSTELE BILHOU-NABERA, NASSERA ABERMIL, HÉLÈNE GUERMOUCHE, ELODIE GOUACHE, GUY LEVERGER, MARIO F FRAGA, AGUSTÍN F FERNÁNDEZ, PAOLA BALLERINI, IGNACIO VARELA EGOCHEAGA, PABLO MENENDEZ

2019

Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs

Article

Blood, 2019, 134(13), 1059-1071

Authorship: SORCHA O´BYRNE, NATALINA ELLIOTT, SIOBHAN RICE, GEMMA BUCK, NICHOLAS FORDHAM, CATHERINE GARNETT, LAURA GODFREY, NICHOLAS T. CRUMP, GARY WRIGHT, SARAH INGLOTT, PENG HUA, BETHAN PSAILA, BENJAMIN POVINELLI, DAVID J. H. F. KNAPP, ANTONIO AGRAZ-DOBLAS, CLARA BUENO, IGNACIO VARELA EGOCHEAGA, PHILLIP BENNETT, HASHEM KOOHY, SUZANNE M. WATT

2019

Unraveling the Cellular Origin and Clinical Prognostic Markers of Infant B-cell Acute Lymphoblastic Leukemia Using Genome-Wide Analysis

Article

Haematologica, 104 (6), 1176-1188 Jun 2019

Authorship: ANTONIO AGRAZ-DOBLAS, CLARA BUENO, RACHAEL BASHFORD-ROGERS, ANINDITA ROY, PAULINE SCHNEIDER, MICHELA BARDINI, PAOLA BALLERINI, GIANNI CAZZANIGA, THAIDY MORENO, CARLOS REVILLA GOMEZ, MARTA GUT, MARIA G. VALSECCHI, IRENE ROBERTS, ROB PIETERS, PAOLA DE LORENZO, IGNACIO VARELA EGOCHEAGA, PABLO MENENDEZ, RONALD W. STAM

2019

Clonal haematopoiesis is not prevalent in survivors of childhood cancer

Article

British Journal of Haematology, 2018, 181(4), 537-539

Authorship: GRACE COLLORD, NAOMI PARK, MARINA PODESTÁ, MONICA DAGNINO, DANIELA CILLONI, DAVID JONES, IGNACIO VARELA EGOCHEAGA, FRANCESCO FRASSONI, GEORGE S. VASSILIOU

01/05/2018

Applied diagnostics in liver cancer: efficient combinations of sorafenib with targeted inhibitors blocking AKT/mTOR

Article

Oncotarget, 2018, 9(56), 30869-30882

Authorship: SUSANA LLERENA SANTIAGO, NURIA GARCIA DIAZ, SORAYA CURIEL DEL OLMO, ANTONIO MANUEL AGRAZ DOBLAS, AGUSTIN GARCIA BLANCO, HELENA PISONERO FRAGA, MARÍA VARELA, MIGUEL SANTIBAÑEZ MARGÜELLO, CARMEN ALMARAZ, LAURA CERECEDA, NEREA MARTÍNEZ, MARIA TERESA ARIAS LOSTE, ÁNGELA PUENTE, LUIS MARTIN RAMOS, CARLOS RODRIGUEZ DE LOPE MARTIN, FEDERICO JOSE CASTILLO SUESCUN, CARMEN CAGIGAS FERNANDEZ, PABLO ISIDRO, CARLOS RODRIGUEZ DE LOPE LOPEZ, MARCOS LOPEZ HOYOS, FRANCISCO JAVIER LLORCA DIAZ, JESUS AGÜERO BALBIN, BENEDICTO CRESPO FACORRO, IGNACIO VARELA EGOCHEAGA, MIGUEL ÁNGEL PIRIS, JAVIER CRESPO GARCIA, JOSE PEDRO VAQUE DIEZ

2018

The MYC antagonist MNT beyond MAX interaction

Conference object

ESMO Open 2018;3(Suppl 2):A157

Authorship: MARIA DEL CARMEN LAFITA NAVARRO, JUDIT LIAÑO PONS, IGNACIO VARELA EGOCHEAGA, ROSA FERNANDA BLANCO FERNÁNDEZ, J. ARESTI, P. CARROLL, P.J. HURLIN, R.N. EISENMAN, MARIA DOLORES DELGADO VILLAR, JAVIER LEON SERRANO

2018

Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes

Article

Nature. 2018 Feb 1;554(7690):62-68

Authorship: SEBASTIAN MUELLER, THOMAS ENGLEITNER, ROMAN MARESCH, MAGDALENA ZUKOWSKA, SEBASTIAN LANGE, THORSTEN KALTENBACHER, BJÖRN KONUKIEWITZ, RUPERT ÖLLINGER, MAXIMILIAN ZWIEBEL, ALEX STRONG, HSI-YU YEN, RUBY BANERJEE, SANDRA LOUZADA, BEIYUAN FU, BARBARA SEIDLER, JULIANA GÖTZFRIED, KATHLEEN SCHUCK, ZONERA HASSAN, ANDREAS ARBEITER, IGNACIO VARELA EGOCHEAGA

01/02/2018

Somatic mutations reveal lineage relationships and age-related mutagenesis in human hematopoiesis

Article

Cell Reports, 2018, 25(9), 2308-2316

Authorship: FERNANDO G. OSORIO, AXEL ROSENDAHL HUBER, RURIKA OKA, MARK VERHEUL, SACHIN H. PATEL, KARLIJN HASAART, LISANNE DE LA FONTEIJNE, IGNACIO VARELA EGOCHEAGA, FERNANDO D. CAMARGO, RUBEN VAN BOXTEL

2018

61 results

1 of 3