Abstract: Patients with symptomatic macromastia (SM) frequently suffer from symptoms related to their breast volume, which negatively impact their quality of life (QoL)1, 2, 3. The most effective treatment for this disease is breast reduction, which provides an improvement in QoL2. In 2009, Pusic et al developed the BREAST-Q® questionnaire4, which is a patient-reported outcome (PRO) instrument specifically designed to measure QoL and satisfaction of patients undergoing surgery; one of the BREAST-Q® modules is dedicated to breast reduction. Although the modules have been linguistically adapted to many different languages ??and thoroughly evaluated using psychometric tests5, 6, 7, they have not been translated into Spanish for the Spanish population. The objectives of this study are to develop a cross-cultural adaptation of the English version of the BREAST-Q® v.2.0 breast reduction module for the Spanish population and to test its reproducibility in our population. To this end, the study included patients with SM treated at our hospital between 2017 and 2018. The selection criteria were applied to patients requesting treatment who had: a body mass index (BMI) ?30?kg/m2, estimated breast resection ?500?g per breast, and age over 18 years. The remaining patients were excluded.

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