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Outcome of kidney transplants from viremic and non-viremic hepatitis C virus positive donors into negative recipients: results of the spanish registry

Abstract: Historically, donor infection with hepatitis-C virus (HCV) has been a barrier to kidney transplantation. However, in recent years, it has been reported that HCV positive kidney donors transplanted into HCV negative recipients offer acceptable mid-term results. However, acceptance of HCV donors, especially viremic, has not broadened in the clinical practice. This is an observational, multicenter, retrospective study including kidney transplants from HCV positive donors into negative recipients reported to the Spanish group from 2013 to 2021. Recipients from viremic donors received peri-transplant treatment with direct antiviral agents (DAA) for 8?12 weeks. We included 75 recipients from 44 HCV non-viremic donors and 41 from 25 HCV viremic donors. Primary non function, delayed graft function, acute rejection rate, renal function at the end of follow up, and patient and graft survival were not different between groups. Viral replication was not detected in recipients from non-viremic donors. Recipient treatment with DAA started pre-transplant avoids (n = 21) or attenuates (n = 5) viral replication but leads to non-different outcomes to post-transplant treatment with DAA (n = 15). HCV seroconversion was more frequent in recipients from viremic donors (73% vs. 16%, p < 0.001). One recipient of a viremic donor died due to hepatocellular carcinoma at 38 months. Donor HCV viremia seems not to be a risk factor for kidney transplant recipients receiving peri-transplant DAA, but continuous surveillance should be advised

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Journal of Clinical Medicine, 2023, 12(5), 1773

Editorial: MDPI

 Año de publicación: 2023

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/jcm12051773

ISSN: 2077-0383

Url de la publicación: https://doi.org/10.3390/jcm12051773

Autores/as

FRANCO, ANTONIO

MORESO, FRANCESC

SOLÀ-PORTA, EULÀLIA

BENEYTO, ISABEL

ESFORZADO, NÚRIA

GONZALEZ-RONCERO, FRANCISCO

SANCHO, ASUNCIÓN

MELILLI, EDUARDO

GALEANO, CRISTINA