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Positron emission computed tomography spectrum of large vessel vasculitis in a tertiary center: differences in 18F-fluorodeoxyglucose uptake between large vessel vasculitis with predominant cranial and extracranial giant cell arteritis phenotypes

Abstract: Objective: To assess the spectrum of PET-CT-related large vessel vasculitis (LVV) in a Spanish tertiary center and to determine whether FDG uptake by PET-CT differs between giant cell arteritis (GCA) with predominant cranial or extracranial phenotypes. Methods: The spectrum of patients diagnosed with LVV by PET-CT in a tertiary referral hospital that cares for 450,000 people over a period of two years was reviewed. Moreover, differences in FDG uptake between LVV-GCA with predominantly cranial and extracranial phenotype were analyzed. Results: Eighty patients were diagnosed with LVV by PET-CT. Most were due to systemic vasculitis (n = 64; 80%), especially GCA (n = 54; 67.5%). Other conditions included the presence of rheumatic diseases (n = 4; 3.2%), tumors (n = 9; 7.2%) and infections (n = 3; 2.4%). LVV-GCA patients with predominant extracranial GCA phenotype were younger (mean ± SD: 68.07 ± 9.91 vs. 75.46 ± 7.64 years; p = 0.017) and had a longer delay to the diagnosis (median [interquartile range] 12 [4-18] vs. 4 [3-8]; p = 0.006), but had polymyalgia rheumatica symptoms more frequently than those with predominantly cranial GCA phenotype (46.3% vs. 15.4%, p = 0.057). When FDG uptake was compared according to the two different disease patterns, no statistically significant differences were observed. However, patients with extracranial LVV-GCA showed a non-significantly higher frequency of vasculitic involvement of lower-extremity arteries. Conclusions: Regardless of the predominant phenotype, LVV identified by PET-CT is more commonly due to GCA in the Spanish population. In these GCA patients, younger age, PMR, and a higher frequency of lower-extremity artery vasculitis suggest the presence of LVV

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: Heras-Recuero E., Landaeta-Kancev L.C., Martínez de Bourio-Allona M., Torres-Rosello A., Blázquez-Sánchez T., Ferraz-Amaro I., Castañeda S., Martínez-López J.A., Martínez-Dhier L., Largo R., González-Gay M.Á.,

 Fuente: Journal of Clinical Medicine, 2023, 12(19), 6164

Editorial: MDPI

 Año de publicación: 2023

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/jcm12196164

ISSN: 2077-0383

Url de la publicación: https://doi.org/10.3390/jcm12196164

Autoría

HERAS-RECUERO, ELENA

LANDAETA-KANCEV, LAURA CRISTINA

MARTÍNEZ DE BOURIO-ALLONA, MARTA

TORRES-ROSELLO, ARANTXA

BLÁZQUEZ-SÁNCHEZ, TERESA

FERRAZ-AMARO, IVÁN

CASTAÑEDA, SANTOS

MARTÍNEZ-LÓPEZ, JUAN ANTONIO

MARTÍNEZ-DHIER, LUIS

LARGO, RAQUEL