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HDL cholesterol efflux and the complement system are linked in systemic lupus erythematosus

Abstract: Cholesterol efflux capacity (CEC), the ability of high-density lipoprotein (HDL) cholesterol to accept cholesterol from macrophages, has been linked to cardiovascular events. Systemic lupus erythematosus (SLE) is characterized by the consumption of complement (C) proteins and has been associated with an increased risk of cardiovascular disease. CEC is reduced in SLE patients compared to controls. In the present work, our objective was to analyze whether the disruption of C influences CEC in patients with SLE. New-generation functional assays of the three pathways of the C system were performed in 207 patients with SLE. Additionally, serum levels of inactive (C1q, C2, C3, C4, and factor D) and activated (C3a) molecules, and regulators (C1-inhibitor and factor H) of C system were measured. CEC, using an in vitro assay, and lipoprotein serum concentrations were assessed. Multivariable linear regression analysis was performed to assess the relationship between C system and CEC. After full multivariable analysis, the alternative C cascade functional test showed a significant and negative relationship with CEC. This was also the case for C2 and C3, in which the associations were found to be positive and statistically significant, after adjustment for covariates. In conclusion, C system and CEC are interconnected in patients with SLE.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Autoría: García-González M., Gómez-Bernal F., Quevedo-Abeledo J.C., Fernández-Cladera Y., González-Rivero A.F., López-Mejías R., Díaz-González F., González-Gay M., Ferraz-Amaro I.,

 Fuente: Journal of Clinical Medicine, 2023, 12, 5405

Editorial: MDPI

 Año de publicación: 2023

Nº de páginas: 11

Tipo de publicación: Artículo de Revista

 DOI: 10.3390/jcm12165405

ISSN: 2077-0383

Autores/as

GARCÍA-GONZÁLEZ, MARÍA

GÓMEZ-BERNAL, FUENSANTA

QUEVEDO-ABELEDO, JUAN C.

FERNÁNDEZ-CLADERA, YOLANDA

GONZÁLEZ-RIVERO, AGUSTÍN F.

LÓPEZ-MEJÍAS, RAQUEL

DÍAZ-GONZÁLEZ, FEDERICO

FERRAZ-AMARO, IVÁN