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A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis.

Abstract: Objective. To investigate whether a functional integrin alpha M (ITGAM) variant is involved in susceptibility to and clinical manifestations of giant cell arteritis (GCA). Methods. A Spanish cohort of 437 white patients with biopsy-proven GCA and 1388 healthy controls were genotyped using the TaqMan allele discrimination technology. Results. No association was observed between ITGAM rs1143679 and GCA (p = 0.80, OR 0.97). Similarly, subphenotype analyses did not yield significant differences between the case subgroups and the control set or between GCA patients with or without the main specific features of GCA. Conclusion. Our results suggest that the ITGAM rs1143679 variant does not play an important role in the pathophysiology of GCA.

 Fuente: The Journal of Rheumatology, 2011, 38(12), 2598-2601

 Editorial: The Journal of Rheumatology Publishing Company Limited

 Fecha de publicación: 01/12/2011

 Nº de páginas: 4

 Tipo de publicación: Artículo de Revista

 DOI: 10.3899/jrheum.110685

 ISSN: 0315-162X

 Url de la publicación: https://doi.org/10.3899/jrheum.110685

Autoría

CARMONA, F. DAVID

SERRANO, AURORA

RODRÍGUEZ-RODRÍGUEZ, LUIS

CASTAÑEDA, SANTOS

MIRANDA-FILLOY, JOSÉ A.

MORADO, INMACULADA C.

NARVÁEZ, JAVIER

SOLANS, ROSER

SOPEÑA, BERNARDO

MARÍ-ALFONSO, BEGOÑA

UNZURRUNZAGA, AINHOA

ORTEGO-CENTENO, NORBERTO

MIGUEL, EUGENIO DE

HIDALGO-CONDE, ANA

MARTÍN, JAVIER