Buscar

Estamos realizando la búsqueda. Por favor, espere...

Evidence for PTPN22 R620W polymorphism as the sole common risk variant for rheumatoid arthritis in the 1p13.2 region.

Abstract: Objective. The PTPN22 rs2476601 genetic variant has been associated with rheumatoid arthritis (RA) and other autoimmune diseases. Some reports suggest that this single-nucleotide polymorphism (SNP) may not be the only causal variant in the region of PTPN22. Our aim was to identify new independent RA-associated common gene variants in the PTPN22 region. Methods. We analyzed Wellcome Trust Case-Control Consortium genome-wide association study data for associations in the 397.2 kb PTPN22 region and selected 9 associated SNP (with p < 5 × 10?3) for replication and dependence analysis. The replication cohorts comprised 2857 patients with RA and 2994 controls from Spain, Netherlands, and Norway. Results. We found that 6 of the 9 selected SNP were associated in the Spanish cohort. Of these, 4 were also associated in the Dutch and Norwegian cohorts, and all 6 were associated with RA in the combined analysis. Conditional analyses showed that none of these associations was independent of rs2476601. Conclusion. The SNP rs2476601 located in the PTPN22 gene is the sole common genetic variant associated with RA in the 1p13.2 region, suggesting that neighbor genes of PTPN22 do not have a major influence in RA.

 Fuente: The Journal of Rheumatology, 2011, 38(11), 2290-2296

 Editorial: The Journal of Rheumatology Publishing Company Limited

 Fecha de publicación: 01/11/2011

 Nº de páginas: 7

 Tipo de publicación: Artículo de Revista

 DOI: 10.3899/jrheum.110361

 ISSN: 0315-162X

 Proyecto español: SAF2009-11110

 Url de la publicación: https://doi.org/10.3899/jrheum.110361

Autoría

MARTÍN, JOSE-EZEQUIEL

ALIZADEH, BEHROOZ Z.

PASCUAL-SALCEDO, DORA

GONZÁLEZ-ESCRIBANO, MARÍA F.

RAYA, ENRIQUE

COENEN, MARIEKE J. H.

RIEL, PIET VAN

RADSTAKE, TIMOTHY R. D. J.

KVIEN, TORE K.

LIE, BENEDICTE A.

KOELEMAN, BOBBY P. C.

MARTÍN, JAVIER