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Evaluation of a shared autoimmune disease-associated polymorphism of TRAF6 in systemic sclerosis and giant cell arteritis.

Abstract: Objective We evaluated whether a single-nucleotide polymorphism (SNP) of the TRAF6 gene previously associated with systemic lupus erythematosus and rheumatoid arthritis may be a common risk factor for systemic sclerosis (SSc) and giant cell arteritis (GCA). Methods A total of 1185 patients with SSc, 479 patients with biopsy-proven GCA, and 1442 unrelated healthy controls of white Spanish origin were genotyped for the rs540386 variant using a specifically designed TaqMan© allele discrimination assay. Results No significant associations of this SNP with global SSc or GCA were found. This was also the case when the potential associations of the TRAF6 polymorphism with the main clinical phenotypes of the 2 diseases (e.g., limited cutaneous and diffuse cutaneous SSc, or presence of polymyalgia rheuma - tica and visual ischemic manifestations in GCA) were assessed. Conclusion Our data do not support a role of the rs540386 TRAF6 variant as a key component of the genetic network underlying SSc and GCA.

 Fuente: The Journal of Rheumatology, 2012, 39(6), 1275-1279

 Editorial: The Journal of Rheumatology Publishing Company Limited

 Fecha de publicación: 01/06/2012

 Nº de páginas: 5

 Tipo de publicación: Artículo de Revista

 DOI: 10.3899/jrheum.120038

 ISSN: 0315-162X

 Proyecto español: SAF2009-11110

 Url de la publicación: https://doi.org/10.3899/jrheum.120038

Autoría

CARMONA, F. DAVID

SERRANO, AURORA

RODRÍGUEZ-RODRÍGUEZ, LUIS

CALLEJAS, JOSÉ LUIS

SIMEÓN, CARMEN P.

CARREIRA, PATRICIA

CASTAÑEDA, SANTOS

SOLANS, ROSER

MARTÍN, JAVIER

ORTEGO-CENTENO, NORBERTO