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Maturity of human bone estimated by FTIR spectroscopy analysis: implications for ostheoporosis

Abstract: This work studies the possible variations of the properties of mineral and organic bone components with regard to the anatomical position and the patient's age. Autopsies of healthy human iliac crest have been analyzed within a wide range of ages (26-88), measuring different anatomical positions in trabecular bone by means of FT-IR spectroscopy. The study was focused on the analysis of v1, v3 phosphate, v2 carbonate amida I and amida II bands. From the resulting spectra the cristallinity/maturity index, the collagen cross-links ratio and the carbonate/phosphate ratio were calculated. All of them provide information of bone mineral and collagen maturity. The results show a trend in the spatial distribution of mineral and collagen maturity in most of the samples. The most mature mineral and collagen of the bone were found to be located in the trabecular center, while the youngest were situated in the peripheral regions. However, this behavior has exceptions that seem to be related with the patient's age.

Other conference communications or articles related to authors from the University of Cantabria

 Authorship: Salas-García I., Fanjul-Vélez F., Ortega-Quijano N., Rada M., Buelta L., Arce-Diego J.,

 Congress: Photonic Therapeutics and Diagnostics (6º . 2010 : San Francisco, California)

 Publisher: SPIE Society of Photo-Optical Instrumentation Engineers

 Publication date: 02/03/2010

 No. of pages: 9

 Publication type: Conference object

 DOI: 10.1117/12.842219

 ISSN: 0277-786X,1996-756X

 Publication Url: https://doi.org/10.1117/12.842219

Authorship

IRENE SALAS GARCIA

NOE ORTEGA QUIJANO

RADA, MANOJ

LUIS BUELTA CARRILLO