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Photosensitizer fluorescence emission during photodynamic therapy applied to dermatological diseases

Abstract: We present a first approach to predict the photosensitizer fluorescence dependence with depth during the Photodynamic Therapy applied to a skin disease commonly treated in the dermatological clinical practice. The obtained results permit us to know the photosensitizer temporal fluorescence evolution in different points of the tumor sample during the photochemical reactions involved in PDT with a predictive purpose related to the treatment evolution. The model presented also takes into account the distribution of a topical photosensitizer, the propagation of light in a biological media and the subsequent photochemical interactions between light and tissue. This implies that different parameters related with the photosensitizer distribution or the optical source characteristics could be adjusted to provide a specific treatment to a particular pathology.

Other conference communications or articles related to authors from the University of Cantabria

 Authorship: Salas-García I., Fanjul-Vélez F., Ortega-Quijano N., Arce-Diego J.,

 Congress: Photonics, Devices and Systems (5ª : 2011 : Praga)

 Publisher: SPIE Society of Photo-Optical Instrumentation Engineers

 Publication date: 11/10/2011

 No. of pages: 7

 Publication type: Conference object

 DOI: 10.1117/12.912065

 ISSN: 0277-786X,1996-756X

 Publication Url: