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Photosensitizer fluorescence emission during photodynamic therapy applied to dermatological diseases

Abstract: We present a first approach to predict the photosensitizer fluorescence dependence with depth during the Photodynamic Therapy applied to a skin disease commonly treated in the dermatological clinical practice. The obtained results permit us to know the photosensitizer temporal fluorescence evolution in different points of the tumor sample during the photochemical reactions involved in PDT with a predictive purpose related to the treatment evolution. The model presented also takes into account the distribution of a topical photosensitizer, the propagation of light in a biological media and the subsequent photochemical interactions between light and tissue. This implies that different parameters related with the photosensitizer distribution or the optical source characteristics could be adjusted to provide a specific treatment to a particular pathology.

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Authorship: Salas-García I., Fanjul-Vélez F., Ortega-Quijano N., Arce-Diego J.,

Congress: Photonics, Devices and Systems (5ª : 2011 : Praga)

Publisher: SPIE Society of Photo-Optical Instrumentation Engineers

Publication date: 11/10/2011

No. of pages: 7

Publication type: Conference object

DOI: 10.1117/12.912065

ISSN: 0277-786X,1996-756X

Publication Url: https://doi.org/10.1117/12.912065

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Authorship

IRENE SALAS GARCIA

FELIX FANJUL VELEZ

NOE ORTEGA QUIJANO

JOSE LUIS ARCE DIEGO

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