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Colorimetric fusion of attenuation and birefringence in OCT signatures: a screening tool for evaluating muscular degradation in alpha-sarcoglican deficit murine models

Abstract: In this work, intensity and polarization OCT were applied, simultaneously, to alpha-sarcoglycan deficit mice models, and a new visualization technique was implemented, based on encoding the attenuation and birefringence values in the HSV color space. Our samples consisted of 14 ex-vivo mice quadriceps at different disease stages (one, three, and six-month-old mice) and four healthy ones for reference. The healthy muscles present a different birefringence distribution to the dystrophic ones, while attenuation values for both kinds of samples lay in the same range. Nevertheless, the attenuation provides an increase in contrast and textural features that are not visible by only using birefringence, while the latter, encoded in the H coordinate, helps to easily identify damage inside the samples by color.

Other conference communications or articles related to authors from the University of Cantabria

 Authorship: Mieites V., Pardo A., Gutiérrez-Gutiérrez J.A., Suárez-Calvet X., López-Higuera J.M., Díaz-Manera J., Conde O.M.,

 Congress: Optical Coherence Imaging Techniques and Imaging in Scattering Media (5ª : 2023 : Múnich)

 Publisher: SPIE Society of Photo-Optical Instrumentation Engineers

 Publication date: 11/08/2023

 No. of pages: 4

 Publication type: Conference object

 DOI: 10.1117/12.2670555

 ISSN: 0277-786X,1996-756X

 Spanish project: PID2019-107270RB-C21

 Publication Url: https://doi.org/10.1117/12.2670555

Authorship

VERONICA MIEITES ALONSO

ARTURO PARDO FRANCO

SUÁREZ CALVET, XAVIER

DÍAZ MANERA, JORDI