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Tanzawaic acids, a chemically novel set of bacterial conjugation inhibitors

Abstract: Bacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance in human pathogens. This dissemination could be controlled by molecules that interfere with the conjugation process. A search for conjugation inhibitors among a collection of 1,632 natural compounds, identified tanzawaic acids A and B as best hits. They specially inhibited IncW and IncFII conjugative systems, including plasmids mobilized by them. Plasmids belonging to IncFI, IncI, IncL/M, IncX and IncH incompatibility groups were targeted to a lesser extent, whereas IncN and IncP plasmids were unaffected. Tanzawaic acids showed reduced toxicity in bacterial, fungal or human cells, when compared to synthetic conjugation inhibitors, opening the possibility of their deployment in complex environments, including natural settings relevant for antibiotic resistance dissemination.

 Fuente: PLoS One, 2016, 11(1), e0148098

 Editorial: Public Library of Science

 Año de publicación: 2016

 Nº de páginas: 13

 Tipo de publicación: Artículo de Revista

 DOI: 10.1371/journal.pone.0148098

 ISSN: 1932-6203

 Proyecto español: BFU2014-55534-C2-1-P

 Url de la publicación: https://www.doi.org/10.1371/journal.pone.0148098

Autoría

MARIA GETINO REDONDO

JAVIER CAMPOS GOMEZ

SÁNCHEZ-LÓPEZ, JOSE M.

MARTÍNEZ, MARTA

FERNÁNDEZ, ANTONIO