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Abstract: Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537) in a large independent European Caucasian population. However, no evidence of association was found for the analyzed CD247 single-nucleotide polymorphisms (SNPs) with RA and with the presence/absence of anti-cyclic citrullinated polypeptide. We performed a meta-analysis including previously published GWAS data from the rs864537 variant, revealing an overall genome-wide significant association between this CD247 SNP and RA with anti-CCP (OR = 0.90, CI 95% = 0.87?0.93, Poverall = .1×10-10). Our results show for first time a GWAS-level association between this CD247 polymorphism and RA risk.
Fuente: PLoS One, 2013, 8(7), e68295
Editorial: Public Library of Science
Año de publicación: 2013
Nº de páginas: 4
Tipo de publicación: Artículo de Revista
DOI: 10.1371/journal.pone.0068295
ISSN: 1932-6203
Url de la publicación: https://doi.org/10.1371/journal.pone.0068295
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TERUEL, MARÍA
MCKINNEY, CUSHLA
BALSA, ALEJANDRO
PASCUL-SALCEDO, DORA
RODRÍGUEZ-RODRÍGUEZ, LUIS
ORTIZ., ANA M.
GÓMEZ-VAQUERO, CARMEN
MIGUEL ANGEL GONZALEZ-GAY MANTECON
SMITH, MALCOLM
WITTE, TORSTEN
MERRIMAN, TONY
LIE, BENEDICTE A.
MARTÍN, JAVIER
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