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Association of CD247 polymorphisms with rheumatoid arthritis: a replication study and a meta-analysis

Abstract: Given the role of CD247 in the response of the T cells, its entailment in autoimmune diseases and in order to better clarify the role of this gene in RA susceptibility, we aimed to analyze CD247 gene variants previously associated with other autoimmune diseases (rs1052237, rs2056626 and rs864537) in a large independent European Caucasian population. However, no evidence of association was found for the analyzed CD247 single-nucleotide polymorphisms (SNPs) with RA and with the presence/absence of anti-cyclic citrullinated polypeptide. We performed a meta-analysis including previously published GWAS data from the rs864537 variant, revealing an overall genome-wide significant association between this CD247 SNP and RA with anti-CCP (OR = 0.90, CI 95% = 0.87?0.93, Poverall = .1×10-10). Our results show for first time a GWAS-level association between this CD247 polymorphism and RA risk.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: PLoS One, 2013, 8(7), e68295

Editorial: Public Library of Science

 Año de publicación: 2013

Nº de páginas: 4

Tipo de publicación: Artículo de Revista

 DOI: 10.1371/journal.pone.0068295

ISSN: 1932-6203

Url de la publicación: https://doi.org/10.1371/journal.pone.0068295

Autoría

TERUEL, MARÍA

MCKINNEY, CUSHLA

BALSA, ALEJANDRO

PASCUL-SALCEDO, DORA

RODRÍGUEZ-RODRÍGUEZ, LUIS

ORTIZ., ANA M.

GÓMEZ-VAQUERO, CARMEN

SMITH, MALCOLM

WITTE, TORSTEN

MERRIMAN, TONY

LIE, BENEDICTE A.

MARTÍN, JAVIER