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The functional polymorphism 844 A>G in FcaRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility.

Abstract: Objective. To investigate the role of the FcaRI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. Methods. The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The FcaRI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. Results. We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. Conclusion. Our data show that the FcaRI 844 A>G polymorphism is not associated with SSc or RA susceptibility.

 Fuente: The Journal of Rheumatology, 2011, 38(3), 446-449

 Editorial: The Journal of Rheumatology Publishing Company Limited

 Fecha de publicación: 01/03/2011

 Nº de páginas: 4

 Tipo de publicación: Artículo de Revista

 DOI: 10.3899/jrheum.100427

 ISSN: 0315-162X

 Proyecto español: SAF2009-11110

 Url de la publicación: https://doi.org/10.3899/jrheum.100427

Autoría

BROEN, JASPER C. A.

COENEN, MARIEKE J. H.

RUEDA, BLANCA

WITTE, TORSTEN

PADYUKOV, LEONID

KLARESKOG, LARS

HESSELSTRAND, ROGER

WUTTGE, DIRK M.

SIMEON, CARMEN

ORTEGO-CENTENO, NORBERTO

HUNZELMAN, NICHOLAS

RIEMEKASTEN, GABRIELA

KREUTER, ALEXANDER

VONK, MADELON

SCORZA, RAFAELLA

BERETTA, LORENZO

AIRÒ, PAULO

RIEL, PIET L. C. M. VAN

KIMBERLY, ROBERT

MARTIN, JAVIER

EDBERG, JEFFREY

RADSTAKE, TIMOTHY R .D. J.