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Abstract: The major environmental risk factor for rheumatoid arthritis (RA) is smoking, which according to a widely accepted model induces protein citrullination in the lungs, triggering the production of anticitrullinated protein antibodies (ACPA) and RA development. Nevertheless, some research findings do not fit this model. Therefore, we obtained six independent cohorts with 2253 RA patients for a detailed analysis of the association between smoking and RA autoantibodies. Our results showed a predominant association of smoking with the concurrent presence of the three antibodies: rheumatoid factor (RF), ACPA and anti-carbamylated protein antibodies (ACarPA) (3 Ab vs. 0 Ab: OR = 1.99, p = 2.5 × 10?8). Meta-analysis with previous data (4491 patients) confirmed the predominant association with the concurrent presence of the three antibodies (3 Ab vs. 0 Ab: OR = 2.00, p = 4.4 ×10?16) and revealed that smoking was exclusively associated with the presence of RF in patients with one or two antibodies (RF+ 1+2 vs. RF? 0+1+2: OR = 1.32, p = 0.0002). In contrast, no specific association with ACPA or ACarPA was found. Therefore, these results showed the need to understand how smoking favors the concordance of RA specific antibodies and RF triggering, perhaps involving smoking-induced epitope spreading and other hypothesized mechanisms.
Fuente: Scientific Reports (2020)10:3355
Publisher: Nature Publishing Group
Year of publication: 2020
No. of pages: 11
Publication type: Article
DOI: 10.1038/s41598-020-60305-x
ISSN: 2045-2322
Publication Url: https://doi.org/10.1038/s41598-020-60305-x
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CRISTINA REGUEIRO
LUIS RODRIGUEZ-RODRIGUEZ
RAQUEL LOPEZ-MEJIAS
LAURA NUÑO
ANA TRIGUERO-MARTINEZ
EVA PEREZ-PAMPIN
ALFONSO CORRALES
ALEJANDRO VILLALBA
YOLANDA LOPEZ-GOLAN
LYDIA ABASOLO
SARA REMUZGO-MARTÍNEZ
ANA M. ORTIZ
EVA HERRANZ
ANA MARTÍNEZ-FEITO
CARMEN CONDE
ANTONIO MERA-VARELA
ALEJANDRO BALSA
ISIDORO GONZALEZ-ALVARO
MIGUEL ANGEL GONZALEZ-GAY MANTECON
BENJAMÍN FERNANDEZ-GUTIERREZ
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