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Feasibility of large-scale population testing for SARS-CoV-2 detection by self-testing at home

Abstract: The simplicity and low cost of rapid point-of-care tests greatly facilitate large-scale population testing, which can contribute to controlling the spread of the COVID-19 virus. We evaluated the applicability of a self-testing strategy for SARS-CoV2 in a population-based, cross-sectional study in Cantabria, Spain, between April and May 2020. For the self-testing strategy, participants received the necessary material for the self-collection of blood and performance of a rapid antibody test using lateral flow immunoassay at home without the supervision of healthcare personnel. A total of 1,022 participants were enrolled. Most participants correctly performed the COVID-19 self-test the first time (91.3% [95% CI 89.4-92.9]). Only a minority of the participants (0.7%) needed the help of healthcare personnel, while 6.9% required a second kit delivery, for a total valid test result in 96.9% of the participants. Incorrect use of the self-test was not associated with the educational level, age over 65, or housing area. Prevalence of IgG antibodies against SARS-CoV2 for subjects with a valid rapid test result was 3.1% (95% CI 2.2-4.4), similar to the seroprevalence result obtained using a conventional approach carried out by healthcare professionals. In conclusion, COVID-19 self-testing should be considered as a screening tool.

 Fuente: Sci Rep . 2021 May 10;11(1):9819

 Publisher: Nature Publishing Group

 Year of publication: 2021

 No. of pages: 10

 Publication type: Article

 DOI: 10.1038/s41598-021-89236-x

 ISSN: 2045-2322

 Publication Url: https://www.doi.org/10.1038/s41598-021-89236-x

Authorship

IRUZUBIETA, PAULA

FERNÁNDEZ-LANAS, TATIANA

RASINES, LAURA

CAYON, LORENA

ÁLVAREZ-CANCELO, ANA

SANTOS-LASO, ALVARO

GARCÍA-BLANCO, AGUSTÍN

CURIEL-OLMO, SORAYA

CABEZAS, JOAQUÍN

WALLMANN, REINHARD

LAZARUS, JEFFREY V

JAVIER CRESPO GARCIA