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Abstract: Solid organ transplant (SOT) recipients are especially at risk of developing infections by multidrug resistant bacteria (MDR). In this study, the biofilm-forming capability of 209 MDR strains (Escherichia coli n = 106, Klebsiella pneumoniae n = 78, and Enterobacter spp. n = 25) isolated from rectal swabs in the first 48 hours before or after kidney (93 patients), liver (60 patients) or kidney/pancreas transplants (5 patients) were evaluated by using a microplate assay. Thirty-nine strains were isolated before transplant and 170 strains were isolated post-transplant. Overall, 16% of E. coli strains, 73% of K. pneumoniae strains and 4% Enterobacter strains showed moderate or strong biofilm production. Nine strains isolated from infection sites after transplantation were responsible of infections in the first month. Of these, 4 K. pneumoniae, 1 E. coli and 1 Enterobacter spp. strains isolated pre-transplant or post-transplant as colonizers caused infections in the post-transplant period. Our results suggest that in vitro biofilm formation could be an important factor for adhesion to intestine and colonization in MDR K. pneumoniae strains in SOT recipients, but this factor appears to be less important for MDR E. coli and Enterobacter spp.
Fuente: Sci Rep 2019 Jun 20;9(1):8928
Publisher: Nature Publishing Group
Year of publication: 2019
No. of pages: 10
Publication type: Article
DOI: 10.1038/s41598-019-45060-y
ISSN: 2045-2322
Publication Url: https://www.doi.org/10.1038/s41598-019-45060-y
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RAMOS-VIVAS, JOSÉ
CHAPARTEGUI-GONZÁLEZ, ITZIAR
FERNÁNDEZ-MARTÍNEZ, MARTA
GONZÁLEZ-RICO, CLAUDIA
FORTÚN, JESÚS
ESCUDERO, ROSA
MARCO, FRANCESC
LINARES, LAURA
MONTEJO, MIGUEL
ARANZAMENDI, MAITANE
MUÑOZ, PATRICIA
VALERIO, MARICELA
AGUADO, JOSE MARÍA
RESINO, ELENA
GRACIA AHUFINGER, IRENE
PAZ VEGA, AURORA
MARTÍNEZ-MARTÍNEZ, LUIS
MARIA DEL CARMEN FARIÑAS ALVAREZ
THE ENTHERE STUDY GROUP
EMILIO FABREGA GARCIA
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