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Defensa de Tesis Doctoral2982012/06/2025 8:10:27https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse197<img alt="" src="/ibbtec/PublishingImages/Events/Tesis%202025-6-13%20Paula%20Perez.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2025-06-12T22:00:00Z<p>​​<br></p>SeminarioPaula Pérez AdriánIBBTEC17_Event
Defensa de Tesis Doctoral2981612/06/2025 8:11:32https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse196<img alt="" src="/ibbtec/PublishingImages/Events/Tesis%202025-6-12%20Arancha%20Penil.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2025-06-11T22:00:00Z<p>​​<br></p>SeminarioArancha Peñil CelisIBBTEC17_Event
Seminario de investigación2987212/06/2025 8:15:40https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse198<img alt="" height="281" src="/ibbtec/PublishingImages/Events/HS2025-6-12%20Aurora%20Gomez.jpg" width="500" style="BORDER&#58;0px solid;MARGIN&#58;5px 5px;" />2025-06-11T22:00:00Z<p>​​<br></p>SeminarioAurora Gómez DuránIBBTEC17_Event
Seminario de investigación5660804/06/2025 12:31:03https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse195<img alt="" src="/ibbtec/PublishingImages/Journals/HS2025-6-5%20Beatriz%20Trastoy.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2025-06-04T22:00:00Z<p>​​</p>SeminarioBeatriz TrastoyIBBTEC17_Event
Progress Report12153430/05/2025 7:17:49Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse173<img alt="" src="/ibbtec/PublishingImages/Events/Seminario%20PR2025-6-4%20Castilla.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2025-06-03T22:00:00Z<p></p><div>Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus proyectos. Las sesiones se celebran semanalmente en el salón de actos del IBBTEC y se imparten en inglés.</div><div><br></div><div><br></div><div>​​El ciclo está coordinado por el investigador del IBBTEC Ramón Merino.​​​​​​​​​​​​​​​​​​<br></div><p>​</p>SeminarioAlejandro Castilla IbeasIBBTEC17_Event
Defensa de Tesis Doctoral12171930/05/2025 8:13:58https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse194<img alt="" src="/ibbtec/PublishingImages/Events/Tesis%202025-5-30%20Mariadel%20Quinonero.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2025-05-29T22:00:00Z<p>​​</p>SeminarioMaría del Mar Quiñonero CoronelIBBTEC17_Event
Seminario de investigación12170712/06/2025 8:16:17https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse189<img alt="" src="/ibbtec/PublishingImages/Events/HS2025-5-29%20Angel%20Carracedo.jpg?Width=500" width="500" style="BORDER&#58;0px solid;MARGIN&#58;5px 5px;" />2025-05-28T22:00:00Z<p>​​<br></p>SeminarioÁngel CarracedoIBBTEC17_Event
Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice.5458504/06/2025 10:27:13Senserrich J, Castro E, Florensa-Zanuy E, Díaz Á, Pazos Á, Adell A, Tzinia A, Pilar-Cuéllar F Abstract Background Major depressive disorder is one of the main causes of https://web.unican.es/ibbtec/es-es/Lists/Papers/AllItems.aspxFalse488<img alt="" src="/ibbtec/PublishingImages/Journals/BOSD.jpg?Width=400" width="400" style="BORDER&#58;0px solid;" />2025-05-21T22:00:00Z<p></p><div><h3>Abstract</h3><div>Background</div><div>Major depressive disorder is one of the main causes of disability worldwide, but its etiopathology remains largely unknown, although several hypotheses have been proposed. Recent studies suggest a potential role for matrix metalloproteinase 9 (MMP-9) in depression, as it is overexpressed in the plasma of depressed patients and normalizes following chronic antidepressant treatment. This study aimed to characterize anxiety and depression-like behaviors in transgenic MMP-9 mice, as well as the expression of different neuroplasticity markers associated with depression, in both sexes.</div><div><br></div><div>Methods</div><div>In this study, we characterized the behavioral phenotypes of both MMP-9 knockout and MMP-9-overexpressing male and female mice. Here, we used a battery of tests to assess anxiety (open field, light‒dark box, elevated plus maze, and novelty‒suppressed feeding tests), depressive-like (tail suspension and social interaction tests), and cognitive (T-maze) behaviors.</div><div><br></div><div>Results</div><div>MMP-9 knockout female mice displayed increased innate anxiety (open field test), decreased behavioral despair (tail suspension test). Compared with control mice, female MMP-9 knockout mice presented increased levels of different neuroplasticity markers in the hippocampus. With respect to MMP-9-overexpressing mice, females presented decreased innate anxiety (elevated plus maze). Male MMP-9-overexpressing mice presented greater conflict-based anxiety (novelty-suppressed feeding test) than control mice did.</div><div><br></div><div>Conclusions</div><div>MMP-9 activity modifies anxiety- and depression-like behaviors, as well as neuroplasticity markers, in female but not in male mice. These findings reinforce the sex differences in the etiopathology of depression.​​<br></div></div>Senserrich J, Castro E, Florensa-Zanuy E, Díaz Á, Pazos Á, Adell A, Tzinia A, Pilar-Cuéllar F.IBBTEC17_Paper
Progress Report12153930/05/2025 7:21:58Nahuel Lofeudo y Daniela Vallejo (IDIVAL Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse175<img alt="" height="281" src="/ibbtec/PublishingImages/Events/Seminario%20PR2025-5-21%20Lofeudo%20y%20Vallejo%20IDIVAL.jpg" width="500" style="BORDER&#58;0px solid;" />2025-05-20T22:00:00Z<p></p><div>Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus proyectos. Las sesiones se celebran semanalmente en el salón de actos del IBBTEC y se imparten en inglés.</div><div><br></div><div><br></div><div>​​El ciclo está coordinado por el investigador del IBBTEC Ramón Merino.​​​​​​​​​​​​​​​​​<br></div><p>​</p>SeminarioNahuel Lofeudo y Daniela Vallejo (IDIVAL)IBBTEC17_Event
Progress Report12154130/05/2025 7:23:00Sandra Moreu y Víctor Sánchez Gaya Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse176<img alt="" src="/ibbtec/PublishingImages/Events/Seminario%20PR2025-5-14%20Moreu%20y%20Sánchez%20Gaya.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2025-05-13T22:00:00Z<p></p><div>Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus proyectos. Las sesiones se celebran semanalmente en el salón de actos del IBBTEC y se imparten en inglés.</div><div><br></div><div><br></div><div>​​El ciclo está coordinado por el investigador del IBBTEC Ramón Merino.​​​​​​​​​​​​​​​​​​<br></div><p>​</p>SeminarioSandra Moreu y Víctor Sánchez GayaIBBTEC17_Event