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Research Seminar8117128/09/2022 8:12:38https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse69<img alt="" height="338" src="/ibbtec/PublishingImages/Events/HS2022-10-4%20Ferrandiz.jpg" width="600" style="BORDER&#58;0px solid;" />2022-10-03T22:00:00Z<p>Nuria Ferrándiz,&#160;investigadora del Centre for Mechanochemical Cell Biology de la Universidad de Warwick, impartirá en el IBBTEC el seminario &quot;Chromosome-membrane ensheathing&#58; unwrapping a mitotic mystery&quot; el próximo 4 de octubre de 2022.<br></p>SeminarioNuria FerrándizIBBTEC17_Event
Defensa de tesis doctoral8006202/09/2022 9:57:15https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse68<img alt="" height="281" src="/ibbtec/PublishingImages/Events/Tesis%202022-9-2%20Sara%20Lucas.jpg" width="500" style="BORDER&#58;0px solid;" />2022-09-01T22:00:00ZSeminarioSara Lucas TocaIBBTEC17_Event
MYC sensitises cells to apoptosis by driving energetic demand14335618/08/2022 8:18:30https://web.unican.es/ibbtec/es-es/Lists/Papers/AllItems.aspxFalse408<img alt="" src="/ibbtec/PublishingImages/Journals/Nature%20Commun.jpeg" style="BORDER&#58;0px solid;" />2022-08-08T22:00:00Z<h3>​Abstract</h3><div><br></div><div>The MYC oncogene is a potent driver of growth and proliferation but also sensitises cells to apoptosis, which limits its oncogenic potential. MYC induces several biosynthetic programmes and primary cells overexpressing MYC are highly sensitive to glutamine withdrawal suggesting that MYC-induced sensitisation to apoptosis may be due to imbalance of metabolic/energetic supply and demand. Here we show that MYC elevates global transcription and translation, even in the absence of glutamine, revealing metabolic demand without corresponding supply. Glutamine withdrawal from MRC-5 fibroblasts depletes key tricarboxylic acid (TCA) cycle metabolites and, in combination with MYC activation, leads to AMP accumulation and nucleotide catabolism indicative of energetic stress. Further analyses reveal that glutamine supports viability through TCA cycle energetics rather than asparagine biosynthesis and that TCA cycle inhibition confers tumour suppression on MYC-driven lymphoma in vivo. In summary, glutamine supports the viability of MYC-overexpressing cells through an energetic rather than a biosynthetic mechanism.<br></div>Joy Edwards-Hicks, Huizhong Su, …Andrew J. FinchIBBTEC17_Paper
Defensa de Tesis Doctoral12432329/07/2022 7:24:07https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse67<img alt="" src="/ibbtec/PublishingImages/Events/Tesis%202022-7-27%20Laura%20Quevedo.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2022-07-26T22:00:00Z<p>​La investigadora del IBBTEC Laura Quevedo, del grupo de Ignacio Varela, defenderá la tesis doctoral “Caracterización genética y funcional de la heterogeneidad intratumoral en un modelo murino de cáncer de páncreas” el miércoles, 27 de julio de 2022, a las 12&#58;30 horas, de forma presencial en el Salón de Actos del IBBTEC.<br></p>SeminarioLaura QuevedoIBBTEC17_Event
Curso “Cómo orientar la investigación para crear impacto socioeconómico”, del 27 de junio al 1 de julio. CSIC-UIMP4727716/06/2022 12:51:22https://web.unican.es/ibbtec/es-es/Lists/News/AllItems.aspxFalse66<img alt="" src="/ibbtec/noticias/PublishingImages/curso_CSIC_UIMP_2022.jpeg" style="BORDER&#58;0px solid;" />2022-06-15T22:00:00Z<p><br></p><p><br></p><p>El CSIC coorganiza un curso de la UIMP en Santander del 27 de junio al 1 de julio dirigido a estudiantes de doctorado&#58;<br></p><div><br></div><div>“Cómo orientar la investigación para crear impacto socioeconómico” (ITC&#58; Intercambio y Transferencia de Conocimiento).</div><div><br></div><div>Es un curso interesante para que los doctorandos se formen en estos temas y contribuyan a transferir a la sociedad los resultados de vuestra investigación. Se imparte en el marco del Programa DINA-ITC (programa de dinamización y formación para fomentar el intercambio y la transferencia de conocimiento en el sistema español de innovación).</div><div><br></div><div>El objetivo de este curso es introducir a los investigadores pre-doctorales en el concepto de Intercambio y Transferencia de Conocimiento</div><div>(ITC), proporcionándoles una serie de conocimientos básicos que les ayuden a reflexionar sobre cómo darle a sus trabajos de investigación una orientación enfocada a responder a necesidades actuales de la sociedad, contribuyendo a lograr impactos de interés social, económico, de salud, tecnológico, etc.</div><div><br></div><div>La formación básica necesaria para el aprovechamiento del curso implica conocimientos y algún tipo de experiencia en la planificación y puesta en marcha de actividades de investigación. Por tanto, este curso está dirigido a estudiantes de doctorado de segundo, tercer o cuarto año.<br></div><div><br></div><div><a href="https&#58;//programa-dinaitc.csic.es/cursos/como-orientar-la-investigacion-para-crear-impacto-socioeconomico/">Más información e inscripciones</a>.<br></div><div><br><br></div><p><br></p>IBBTEC17_News
Progress Report12722524/05/2022 7:52:58https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse662022-05-31T22:00:00Z<p>​Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que&#160;los jóvenes investigadores del IBBTEC y del IDIVAL&#160;presentan el estado actual de sus proyectos. Las sesiones se celebran semanalmente en las instalaciones del IBBTEC –aunque&#160;actualmente se realizan de forma semipresencial, por lo que pueden seguirse online–, y se imparten en inglés.&#160;</p><div><br></div><div>El ciclo está coordinado por el investigador del IBBTEC Ramón Merino.<br></div><p><br></p>SeminarioLara Zorro y Paula PérezIBBTEC17_Event
Characterisation of a nucleo-adhesome13440314/06/2022 6:36:35https://web.unican.es/ibbtec/es-es/Lists/Papers/AllItems.aspxFalse407<img alt="" src="/ibbtec/PublishingImages/Journals/Nature%20Commun.jpeg" style="BORDER&#58;0px solid;" />2022-05-31T22:00:00Z<h3>Abstract<br></h3><div><br></div><div>In addition to central functions in cell adhesion signalling, integrin-associated proteins have wider roles at sites distal to adhesion receptors. In experimentally defined adhesomes, we noticed that there is clear enrichment of proteins that localise to the nucleus, and conversely, we now report that nuclear proteomes contain a class of adhesome components that localise to the nucleus. We here define a nucleo-adhesome, providing experimental evidence for a remarkable scale of nuclear localisation of adhesion proteins, establishing a framework for interrogating nuclear adhesion protein functions. Adding to nuclear FAK's known roles in regulating transcription, we now show that nuclear FAK regulates expression of many adhesion-related proteins that localise to the nucleus and that nuclear FAK binds to the adhesome component and nuclear protein Hic-5. FAK and Hic-5 work together in the nucleus, co-regulating a subset of genes transcriptionally. We demonstrate the principle that there are subcomplexes of nuclear adhesion proteins that cooperate to control transcription.<br></div>Byron A, Griffith BGC, Herrero A et al.IBBTEC17_Paper
The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function14272812/05/2022 10:08:02https://web.unican.es/ibbtec/es-es/Lists/Papers/AllItems.aspxFalse405<img alt="" src="/ibbtec/PublishingImages/Journals/Oncogene%2019.png" width="301" style="BORDER&#58;0px solid;" />2022-05-08T22:00:00Z<h3>​Abstract<br></h3><div><br></div><div>It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this issue, we have used here mouse models in which the activity of guanosine nucleotide exchange factors of the Vav subfamily has been manipulated using both gain- and loss-of-function strategies. These experiments indicate that Vav2 and Vav3 regulate the number, functional status, and responsiveness of hair follicle bulge stem cells. This is linked to gene expression programs related to the reinforcement of the identity and the quiescent state of normal SSCs. By contrast, in the case of cancer stem cells, they promote transcriptomal programs associated with the identity, activation state, and cytoskeletal remodeling. These results underscore the role of these Rho exchange factors in the regulation of normal and tumor epidermal stem cells.<br></div>Lorenzo-Martín LF, Menacho-Márquez M, Fernández-Parejo N, Rodríguez-Fdez S, Pascual G, Abad A, Crespo P, Dosil M, Benitah SA, Bustelo XRIBBTEC17_Paper
Seminario de Doctorado12684825/04/2022 7:43:16https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse622022-05-03T22:00:00ZSeminarioJúlia SenserrichIBBTEC17_Event
Molecular Signaling Mechanisms for the Antidepressant Effects of NLX-101, a Selective Cortical 5-HT 1A Receptor Biased Agonist13042006/05/2022 12:00:06https://web.unican.es/ibbtec/es-es/Lists/Papers/AllItems.aspxFalse403<img alt="" src="/ibbtec/PublishingImages/Journals/big_cover-pharmaceuticals-v15-i3.jpg" width="282" style="BORDER&#58;0px solid;" />2022-04-14T22:00:00Z<h3>​Abstract<br></h3><div><br></div><div><br></div><div>Depression is the most prevalent of the mental illnesses and serotonin (5-hydroxytryptamine, 5-HT) is considered to be the major neurotransmitter involved in its etiology and treatment. In this context, 5-HT1A receptors have attracted interest as targets for therapeutic intervention. Notably the activation of presynaptic 5-HT1A autoreceptors delays antidepressant effects whereas the stimulation of postsynaptic 5-HT1A heteroreceptors is needed for an antidepressant action. NLX-101 (also known as F15599) is a selective biased agonist which exhibits preferred activation of cortical over brain stem 5-HT1A receptors. Here, we used behavioral, neurochemical and molecular methods to examine the antidepressant-like effects in rats of a single dose of NLX-101 (0.16 mg/kg, i.p.). NLX-101 reduced immobility in the forced swim test when measured 30 min but not 24 h after drug administration. NLX-101 increased extracellular concentrations of glutamate and dopamine in the medial prefrontal cortex, but no changes were detected in the efflux of noradrenaline or 5-HT. NLX-101 also produced an increase in the activation of pmTOR, pERK1/2 and pAkt, and the expression of PSD95 and GluA1, which may contribute to its rapid antidepressant action.<br></div>Cabanu S, Pilar-Cuéllar F, Zubakina P, Florensa-Zanuy E, Senserrich J, Newman-Tancredi A, Adell A.IBBTEC17_Paper