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Seminario de investigación24245017/05/2024 12:59:16Leyre Urigüen (Universidad del País Vasco Seminario de Investigación Título Patient-derived neural stem cells for the identification of biomarkers in neuropsychiatric and https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse144<img alt="" src="/ibbtec/PublishingImages/Events/HS2024-5-23%20Leyre%20Urigüen.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2024-05-22T22:00:00Z<p></p><h3>Seminario de Investigación</h3><p><br></p><div><p>Título&#58; Patient-derived neural stem cells for the identification of biomarkers in neuropsychiatric and neurodegenerative diseases<br>Ponente&#58; Leyre Urigüen (Universidad del País Vasco)<br>Host&#58; Albert Adell<br>Fecha y hora&#58; Jueves 23 de mayo de 2024, 13 h<br>Lugar&#58;&#160;Salón de Actos del IBBTEC</p>​<br></div><p>​</p>SeminarioLeyre Urigüen (Universidad del País Vasco)IBBTEC17_Event
Progress Report24244817/05/2024 12:57:13Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse143<img alt="" src="/ibbtec/PublishingImages/Events/Seminario%20PR2024-5-22%20Irene%20Mate%20y%20Ekaterina%20Noskova.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2024-05-21T22:00:00Z<p>​Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus proyectos. Las sesiones se celebran semanalmente en el salón de actos del IBBTEC y se imparten en inglés.</p> <br>​ <p>​​El ciclo está coordinado por el investigador del IBBTEC Ramón Merino.​​​​​​​​​​​​​​​​</p>SeminarioIrene Mate y Ekaterina NoskocaIBBTEC17_Event
Stefan Mundlos en el IBBTEC18875413/05/2024 9:57:44El genetista alemán Stefan Mundlos visitó el jueves 9 de mayo el IBBTEC para impartir el seminario de investigación 'Topologically Associated Domains (TADs) define regulatory 8https://web.unican.es/ibbtec/es-es/Lists/News/AllItems.aspxFalse87<img alt="Stefan Mundlos y Marian Ros" src="/ibbtec/es-es/PublishingImages/Lists/News/AllItems/Visita-Mundlos.jpg" width="1000" style="BORDER&#58;0px solid;" />2024-05-12T22:00:00Z<p>​El genetista alemán Stefan Mundlos&#160;visitó el jueves 9 de mayo el IBBTEC para impartir el seminario de investigación 'Topologically Associated Domains (TADs) define regulatory units of the genome. Lessons learnt from development, disease and evolution​'.<br></p><p>El Dr. Mundlos es director del Instituto de Genética Médica y Humana de la Charité y líder del Grupo de Investigación Desarrollo y Enfermedades del Instituto Max Planck de Genética Molecular. El objetivo principal de su investigación es comprender los mecanismos genéticos del desarrollo normal y anormal, con especial atención al esqueleto. Los mecanismos de regulación genética y cómo se ven influenciados por la variación genómica son un aspecto importante de su trabajo actual.<br></p><p>En su seminario, Mundlos presentó sus recientes&#160;investigaciones sobre cómo la estructura tridimensional de la cromatina influye&#160;en la regulación de la expresión génica al limitar las interacciones entre las secuencias reguladoras y sus genes diana. Este enfoque ha sido fundamental para entender los mecanismos genéticos tanto del desarrollo normal como del anormal. Además, expuso sus nuevos proyectos que incluyen el uso de la genómica sintética para introducir nuevas regiones regulatorias en el genoma del ratón.</p><p>Además, Mundlos&#160;mantuvo varios encuentros con científicos del IBBTEC para conocer de primera mano las líneas de trabajo de diversos&#160;grupos de investigación&#160;del&#160;Instituto.​<br></p><p><br></p><p>(en la imagen, Stefan&#160;Mundlos junto a su anfitriona en el IBBTEC, la Profesora de Investigación Marian Ros)<br></p>IBBTEC17_News
Seminario de doctorado24621409/05/2024 7:54:49Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse141<img alt="" src="/ibbtec/PublishingImages/Events/Seminario%20Doc2024-5-10%20Aurora%20Martín.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2024-05-09T22:00:00Z<p></p><div>Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus proyectos. Las sesiones se celebran semanalmente en el salón de actos del IBBTEC y se imparten en inglés. ​​ ​​<br></div><div><br></div><div>​El ciclo está coordinado por el investigador del IBBTEC Ramón Merino.​​​​​​​​​​​​<br></div>SeminarioAurora MartínIBBTEC17_Event
Regulation of Myc transcription by an enhancer cluster dedicated to pluripotency and early embryonic expression24651514/05/2024 7:58:04Li-Bao L, Díaz-Díaz C, Raiola M, Sierra R, Temiño S, Moya FJ, Rodriguez-Perales S, Santos E, Giovinazzo G, Bleckwehl T, Rada-Iglesias Á, Spitz F, Torres M https://web.unican.es/ibbtec/es-es/Lists/Papers/AllItems.aspxFalse462<img alt="" src="/ibbtec/PublishingImages/Journals/Nature%20Commun.jpeg" style="BORDER&#58;0px solid;" />2024-05-09T22:00:00Z<h3>​​​​Abstract<br></h3><div><br></div><div>MYC plays various roles in pluripotent stem cells, including the promotion of somatic cell reprogramming to pluripotency, the regulation of cell competition and the control of embryonic diapause. However, how Myc expression is regulated in this context remains unknown. The Myc gene lies within a ~ 3-megabase gene desert with multiple cis-regulatory elements. Here we use genomic rearrangements, transgenesis and targeted mutation to analyse Myc regulation in early mouse embryos and pluripotent stem cells. We identify a topologically-associated region that homes enhancers dedicated to Myc transcriptional regulation in stem cells of the pre-implantation and early post-implantation embryo. Within this region, we identify elements exclusively dedicated to Myc regulation in pluripotent cells, with distinct enhancers that sequentially activate during naive and formative pluripotency. Deletion of pluripotency-specific enhancers dampens embryonic stem cell competitive ability. These results identify a topologically defined enhancer cluster dedicated to early embryonic expression and uncover a modular mechanism for the regulation of Myc expression in different states of pluripotency.​​​<br></div>Li-Bao L, Díaz-Díaz C, Raiola M, Sierra R, Temiño S, Moya FJ, Rodriguez-Perales S, Santos E, Giovinazzo G, Bleckwehl T, Rada-Iglesias Á, Spitz F, Torres M.IBBTEC17_Paper
Specificities and commonalities of the Planctomycetes plasmidome.24651714/05/2024 8:30:31Quiñonero-Coronel MDM, Devos DP, Garcillán-Barcia MP Abstract Plasmids, despite their critical role in antibiotic resistance and modern biotechnology, are understood in only a https://web.unican.es/ibbtec/es-es/Lists/Papers/AllItems.aspxFalse463<img alt="" height="658" src="/ibbtec/PublishingImages/Journals/Environ%20Microbiol%2026-5.jpg?Width=600" width="500" style="BORDER&#58;0px solid;" />2024-05-09T22:00:00Z<p></p><h3>Abstract<br></h3><div><br></div><div>Plasmids, despite their critical role in antibiotic resistance and modern biotechnology, are understood in only a few bacterial groups in terms of their natural ecological dynamics. The bacterial phylum Planctomycetes, known for its unique molecular and cellular biology, has a largely unexplored plasmidome. This study offers a thorough exploration of the diversity of natural plasmids within Planctomycetes, which could serve as a foundation for developing various genetic research tools for this phylum. Planctomycetes plasmids encode a broad range of biological functions and appear to have coevolved significantly with their host chromosomes, sharing many homologues. Recent transfer events of insertion sequences between cohabiting chromosomes and plasmids were also observed. Interestingly, 64% of plasmid genes are distantly related to either chromosomally encoded genes or have homologues in plasmids from other bacterial groups. The planctomycetal plasmidome is composed of 36% exclusive proteins. Most planctomycetal plasmids encode a replication initiation protein from the Replication Protein A family near a putative iteron-containing replication origin, as well as active type I partition systems. The identification of one conjugative and three mobilizable plasmids suggests the occurrence of horizontal gene transfer via conjugation within this phylum. This comprehensive description enhances our understanding of the plasmidome of Planctomycetes and its potential implications in antibiotic resistance and biotechnology.​<br></div><p><br><br></p>Quiñonero-Coronel MDM, Devos DP, Garcillán-Barcia MP.IBBTEC17_Paper
Seminario de investigación24621109/05/2024 7:53:08Seminario de Investigación Título Topologically Associated Domains (TADs) define regulatory units of the genome Lessons learnt from development, disease and evolution Ponente https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse140<img alt="" src="/ibbtec/PublishingImages/Events/HS2024-5-9%20Stefan%20Mundlos.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2024-05-08T22:00:00Z<p></p><ul style="list-style-type&#58;disc;"><li><strong>Seminario de Investigación</strong><br>Título&#58; Topologically Associated Domains (TADs) define regulatory units of the genome. Lessons learnt from development, disease and evolution<br>Ponente&#58; Stefan Mundlos – Max Planck Institute for Molecular Genetics (Alemania)<br>Host&#58; Marian Ros<br>Fecha y hora&#58; Jueves 9 de mayo de 2024, 13 h<br>Lugar&#58;&#160;Salón de Actos del IBBTEC<br></li></ul>SeminarioStefan Mundlos (Max Planck Institute) IBBTEC17_Event
Progress Report22937614/05/2024 10:41:39Andrea Fernández Gómez y Víctor Sánchez Gaya Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse139<img alt="" src="/ibbtec/PublishingImages/Events/Seminario%20PR2024-5-8%20Andrea%20Fernandez%20y%20Victor%20Sanchez.jpg?Width=500" width="500" style="BORDER&#58;0px solid;" />2024-05-07T22:00:00Z<p>Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus proyectos. Las sesiones se celebran semanalmente en el salón de actos del IBBTEC y se imparten en inglés.</p> <br> <br> <p>​El ciclo está coordinado por el investigador del IBBTEC Ramón Merino.​​​​​​​​​​​​​​​</p>SeminarioAndrea Fernández Gómez y Víctor Sánchez GayaIBBTEC17_Event
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function22270430/04/2024 6:32:13Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Güller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E https://web.unican.es/ibbtec/es-es/Lists/Papers/AllItems.aspxFalse459<img alt="" src="/ibbtec/PublishingImages/Journals/Nature%20Metabolism.png?Width=400" width="400" style="BORDER&#58;0px solid;" />2024-04-28T22:00:00Z<h3>​​Abstract</h3><div><br></div><div>Promoting brown adipose tissue (BAT) activity innovatively targets obesity and metabolic disease. While thermogenic activation of BAT is well understood, the rheostatic regulation of BAT to avoid excessive energy dissipation remains ill-defined. Here, we demonstrate that adenylyl cyclase 3 (AC3) is key for BAT function. We identified a cold-inducible promoter that generates a 5′ truncated AC3 mRNA isoform (Adcy3-at), whose expression is driven by a cold-induced, truncated isoform of PPARGC1A (PPARGC1A-AT). Male mice lacking Adcy3-at display increased energy expenditure and are resistant to obesity and ensuing metabolic imbalances. Mouse and human AC3-AT are retained in the endoplasmic reticulum, unable to translocate to the plasma membrane and lack enzymatic activity. AC3-AT interacts with AC3 and sequesters it in the endoplasmic reticulum, reducing the pool of adenylyl cyclases available for G-protein-mediated cAMP synthesis. Thus, AC3-AT acts as a cold-induced rheostat in BAT, limiting adverse consequences of cAMP activity during chronic BAT activation.<br></div>Khani S, Topel H, Kardinal R, Tavanez AR, Josephrajan A, Larsen BDM, Gaudry MJ, Leyendecker P, Egedal NM, Güller AS, Stanic N, Ruppert PMM, Gaziano I, Hansmeier NR, Schmidt E, Klemm P, Vagliano LM, Stahl R, Duthie F, Krause JH, Bici A, Engelhard CA, GohlkIBBTEC17_Paper
Seminario de investigación3729610/04/2024 6:41:17Título “Temporal constraints on enhancer usage shape the regulation of limb gene transcription Department of Genetic Medicine and Development, Université de Genève, Switzerland https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspxFalse137<img alt="" src="/ibbtec/PublishingImages/Events/HS2024-4-18%20Raquel%20Rouco.jpg?Width=400" width="400" style="BORDER&#58;0px solid;" />2024-04-17T22:00:00Z<p></p>Título&#58; “Temporal constraints on enhancer usage shape the regulation of limb gene transcription”.​<br><div>Ponente&#58; Dr. Raquel Rouco García. Department of Genetic Medicine and Development, Université de Genève, Switzerland</div><br><div>Fecha y hora del seminario&#58; Jueves 18 de Abril a las 13&#58;00h<br></div><div>Lugar&#58; Salón de actos del IBBTEC<br></div><p>​</p>SeminarioRaquel Rouco García (Univ. de Ginebra, Suiza)IBBTEC17_Event