| Defensa de Tesis Doctoral | 29820 | | | 12/06/2025 8:10:27 | | | https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspx | | False | | | | | 197 | | <img alt="" src="/ibbtec/PublishingImages/Events/Tesis%202025-6-13%20Paula%20Perez.jpg?Width=500" width="500" style="BORDER:0px solid;" /> | | 2025-06-12T22:00:00Z | <p><br></p> | Seminario | Paula Pérez Adrián | IBBTEC17_Event | | | | | |
| Defensa de Tesis Doctoral | 29816 | | | 12/06/2025 8:11:32 | | | https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspx | | False | | | | | 196 | | <img alt="" src="/ibbtec/PublishingImages/Events/Tesis%202025-6-12%20Arancha%20Penil.jpg?Width=500" width="500" style="BORDER:0px solid;" /> | | 2025-06-11T22:00:00Z | <p><br></p> | Seminario | Arancha Peñil Celis | IBBTEC17_Event | | | | | |
| Seminario de investigación | 29872 | | | 12/06/2025 8:15:40 | | | https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspx | | False | | | | | 198 | | <img alt="" height="281" src="/ibbtec/PublishingImages/Events/HS2025-6-12%20Aurora%20Gomez.jpg" width="500" style="BORDER:0px solid;MARGIN:5px 5px;" /> | | 2025-06-11T22:00:00Z | <p><br></p> | Seminario | Aurora Gómez Durán | IBBTEC17_Event | | | | | |
| Seminario de investigación | 56608 | | | 04/06/2025 12:31:03 | | | https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspx | | False | | | | | 195 | | <img alt="" src="/ibbtec/PublishingImages/Journals/HS2025-6-5%20Beatriz%20Trastoy.jpg?Width=500" width="500" style="BORDER:0px solid;" /> | | 2025-06-04T22:00:00Z | <p></p> | Seminario | Beatriz Trastoy | IBBTEC17_Event | | | | | |
| Progress Report | 121534 | | | 30/05/2025 7:17:49 | Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus | | https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspx | | False | | | | | 173 | | <img alt="" src="/ibbtec/PublishingImages/Events/Seminario%20PR2025-6-4%20Castilla.jpg?Width=500" width="500" style="BORDER:0px solid;" /> | | 2025-06-03T22:00:00Z | <p></p><div>Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus proyectos. Las sesiones se celebran semanalmente en el salón de actos del IBBTEC y se imparten en inglés.</div><div><br></div><div><br></div><div>El ciclo está coordinado por el investigador del IBBTEC Ramón Merino.<br></div><p></p> | Seminario | Alejandro Castilla Ibeas | IBBTEC17_Event | | | | | |
| Defensa de Tesis Doctoral | 121719 | | | 30/05/2025 8:13:58 | | | https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspx | | False | | | | | 194 | | <img alt="" src="/ibbtec/PublishingImages/Events/Tesis%202025-5-30%20Mariadel%20Quinonero.jpg?Width=500" width="500" style="BORDER:0px solid;" /> | | 2025-05-29T22:00:00Z | <p></p> | Seminario | María del Mar Quiñonero Coronel | IBBTEC17_Event | | | | | |
| Seminario de investigación | 121707 | | | 12/06/2025 8:16:17 | | | https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspx | | False | | | | | 189 | | <img alt="" src="/ibbtec/PublishingImages/Events/HS2025-5-29%20Angel%20Carracedo.jpg?Width=500" width="500" style="BORDER:0px solid;MARGIN:5px 5px;" /> | | 2025-05-28T22:00:00Z | <p><br></p> | Seminario | Ángel Carracedo | IBBTEC17_Event | | | | | |
| Sex differences in the modulation of anxiety- and depression-like behaviors by matrix metalloproteinase-9 expression levels in mice. | 54585 | | | 04/06/2025 10:27:13 | Senserrich J, Castro E, Florensa-Zanuy E, Díaz Á, Pazos Á, Adell A, Tzinia A, Pilar-Cuéllar F Abstract Background Major depressive disorder is one of the main causes of | | https://web.unican.es/ibbtec/es-es/Lists/Papers/AllItems.aspx | | False | | | | | 488 | | <img alt="" src="/ibbtec/PublishingImages/Journals/BOSD.jpg?Width=400" width="400" style="BORDER:0px solid;" /> | | 2025-05-21T22:00:00Z | <p></p><div><h3>Abstract</h3><div>Background</div><div>Major depressive disorder is one of the main causes of disability worldwide, but its etiopathology remains largely unknown, although several hypotheses have been proposed. Recent studies suggest a potential role for matrix metalloproteinase 9 (MMP-9) in depression, as it is overexpressed in the plasma of depressed patients and normalizes following chronic antidepressant treatment. This study aimed to characterize anxiety and depression-like behaviors in transgenic MMP-9 mice, as well as the expression of different neuroplasticity markers associated with depression, in both sexes.</div><div><br></div><div>Methods</div><div>In this study, we characterized the behavioral phenotypes of both MMP-9 knockout and MMP-9-overexpressing male and female mice. Here, we used a battery of tests to assess anxiety (open field, light‒dark box, elevated plus maze, and novelty‒suppressed feeding tests), depressive-like (tail suspension and social interaction tests), and cognitive (T-maze) behaviors.</div><div><br></div><div>Results</div><div>MMP-9 knockout female mice displayed increased innate anxiety (open field test), decreased behavioral despair (tail suspension test). Compared with control mice, female MMP-9 knockout mice presented increased levels of different neuroplasticity markers in the hippocampus. With respect to MMP-9-overexpressing mice, females presented decreased innate anxiety (elevated plus maze). Male MMP-9-overexpressing mice presented greater conflict-based anxiety (novelty-suppressed feeding test) than control mice did.</div><div><br></div><div>Conclusions</div><div>MMP-9 activity modifies anxiety- and depression-like behaviors, as well as neuroplasticity markers, in female but not in male mice. These findings reinforce the sex differences in the etiopathology of depression.<br></div></div> | | Senserrich J, Castro E, Florensa-Zanuy E, Díaz Á, Pazos Á, Adell A, Tzinia A, Pilar-Cuéllar F. | IBBTEC17_Paper | | | | | |
| Progress Report | 121539 | | | 30/05/2025 7:21:58 | Nahuel Lofeudo y Daniela Vallejo (IDIVAL Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL | | https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspx | | False | | | | | 175 | | <img alt="" height="281" src="/ibbtec/PublishingImages/Events/Seminario%20PR2025-5-21%20Lofeudo%20y%20Vallejo%20IDIVAL.jpg" width="500" style="BORDER:0px solid;" /> | | 2025-05-20T22:00:00Z | <p></p><div>Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus proyectos. Las sesiones se celebran semanalmente en el salón de actos del IBBTEC y se imparten en inglés.</div><div><br></div><div><br></div><div>El ciclo está coordinado por el investigador del IBBTEC Ramón Merino.<br></div><p></p> | Seminario | Nahuel Lofeudo y Daniela Vallejo (IDIVAL) | IBBTEC17_Event | | | | | |
| Progress Report | 121541 | | | 30/05/2025 7:23:00 | Sandra Moreu y Víctor Sánchez Gaya Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL | | https://web.unican.es/ibbtec/es-es/Lists/Events/AllItems.aspx | | False | | | | | 176 | | <img alt="" src="/ibbtec/PublishingImages/Events/Seminario%20PR2025-5-14%20Moreu%20y%20Sánchez%20Gaya.jpg?Width=500" width="500" style="BORDER:0px solid;" /> | | 2025-05-13T22:00:00Z | <p></p><div>Los Progress Reports del IBBTEC son un ciclo de seminarios de investigación en el que los jóvenes investigadores del IBBTEC y del IDIVAL presentan el estado actual de sus proyectos. Las sesiones se celebran semanalmente en el salón de actos del IBBTEC y se imparten en inglés.</div><div><br></div><div><br></div><div>El ciclo está coordinado por el investigador del IBBTEC Ramón Merino.<br></div><p></p> | Seminario | Sandra Moreu y Víctor Sánchez Gaya | IBBTEC17_Event | | | | | |
