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Tocilizumab in uveitis refractory to other biologic drugs: a study of 3 cases and a literature review

Abstract: OBJECTIVES: To evaluate the clinical response to Tocilizumab (TCZ) in three patients with non-infectious uveitis refractory to anti-TNF-a drugs. METHODS: Assessment of TCZ-treated patients with immune-mediated uveitis from two Spanish medical referral centers. Uveitis had been refractory to previous standard synthetic immunosuppressive drugs and at least one TNF-a inhibitor. A literature review of patients with immune-mediated uveitis treated with TCZ therapy was also conducted. RESULTS: 3 women (5 eyes) with uveitis refractory to conventional immunosuppressive therapy and at least one anti-TNF-a drug were treated with TCZ. The mean age of the patients was 48.6±16.1 (range 37-67) years. In two cases uveitis was bilateral and in the other unilateral. The underlying diseases were rheumatoid arthritis in one case and Behçet's disease in the other two cases. After a mean follow-up of 7.3±5.7 (range 1-12) months using TCZ therapy, all patients experienced ocular improvement. Also, in 3 eyes inactive intraocular inflammation was achieved. None of the patients had side effects during the period of treatment with this drug. A literature review disclosed that our observations are in keeping with other reports that showed good response to TCZ in 11 of 12 patients with immune-mediated uveitis refractory to other biologic agents. CONCLUSIONS: TCZ appears to be an effective and safe therapy for the management of patients with uveitis refractory to other biologic drugs.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Clin Exp Rheumatol. 2014 Jul-Aug;32(4 Suppl 84):S54-7

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2014

Nº de páginas: 4

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Proyecto español: RD08/0075 ; RD12/0009/0013

Autores/as

CALVO RÍO, VANESA

HERA, DAVID DE LA

BELTRÁN CATALÁN, EMMA

RICARDO BLANCO ALONSO

HERNÁNDEZ, MARISA

MARTÍNEZ COSTA, LUCÍA

LORICERA, JAVIER

ORTIZ SANJUÁN, FRANCISCO

PINA MURCIA, TRINITARIO

MARIA PAZ RODRIGUEZ CUNDIN