Buscar

Estamos realizando la búsqueda. Por favor, espere...

Tocilizumab in uveitis refractory to other biologic drugs: a study of 3 cases and a literature review

Abstract: Objectives: To evaluate the clinical response to Tocilizumab (TCZ) in three patients with non-infectious uveitis refractory to anti-TNF-a drugs. Methods: Assessment of TCZ-treated patients with immune-mediated uveitis from two Spanish medical referral centers. Uveitis had been refractory to previous standard synthetic immunosuppressive drugs and at least one TNF-a inhibitor. A literature review of patients with immune-mediated uveitis treated with TCZ therapy was also conducted. Results: 3 women (5 eyes) with uveitis refractory to conventional immunosuppressive therapy and at least one anti-TNF-a drug were treated with TCZ. The mean age of the patients was 48.6±16.1 (range 37-67) years. In two cases uveitis was bilateral and in the other unilateral. The underlying diseases were rheumatoid arthritis in one case and Behçet's disease in the other two cases. After a mean follow-up of 7.3±5.7 (range 1-12) months using TCZ therapy, all patients experienced ocular improvement. Also, in 3 eyes inactive intraocular inflammation was achieved. None of the patients had side effects during the period of treatment with this drug. A literature review disclosed that our observations are in keeping with other reports that showed good response to TCZ in 11 of 12 patients with immune-mediated uveitis refractory to other biologic agents. Conclusions: TCZ appears to be an effective and safe therapy for the management of patients with uveitis refractory to other biologic drugs.

 Fuente: Clinical and Experimental Rheumatology, 2014, 32(S84), S54-S57

 Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2014

 Nº de páginas: 4

 Tipo de publicación: Artículo de Revista

 ISSN: 0392-856X,1593-098X

 Proyecto español: RD08/0075/022

Autoría

CALVO RÍO, VANESA

HERA, DAVID DE LA

BELTRÁN CATALÁN, EMMA

HERNÁNDEZ, MARISA

MARTÍNEZ COSTA, LUCÍA

LORICERA, JAVIER

ORTIZ SANJUÁN, FRANCISCO

PINA MURCIA, TRINITARIO

MARIA CARMEN GONZALEZ VELA

MARIA PAZ RODRIGUEZ CUNDIN