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Abstract: The debate about surgical resection of primary tumor (PT) in de novo metastatic breast cancer (MBC) patients persists. We explored this approach's outcomes in patients included in a retrospective registry, named El Álamo, of breast cancer patients diagnosed in Spain (1990-2001). In this analysis we only included de novo MBC patients, 1415 of whom met the study's criteria. Descriptive, Kaplan-Meier and Cox regression analyses were carried out. Median age was 63.1 years, 49.2% of patients had single-organ metastasis (skin/soft tissue [16.3%], bone [33.8%], or viscera [48.3%]). PT surgery (S) was performed in 44.5% of the cases. S-group patients were younger, had smaller tumors, higher prevalence of bone and oligometastatic disease, and lower prevalence of visceral involvement. With a median follow-up of 23.3 months, overall survival (OS) was 39.6 versus 22.4 months (HR = 0.59, p < 0.0001) in the S- and non-S groups, respectively. The S-group OS benefit remained statistically and clinically significant regardless of metastatic location, histological type, histological grade, hormone receptor status and tumor size. PT surgery (versus no surgery) was associated with an OS benefit suggesting that loco-regional PT control may be considered in selected MBC patients. Data from randomized controlled trials are of utmost importance to confirm these results.
Fuente: Sci Rep . 2019 Dec 27;9(1):20081
Editorial: Nature Publishing Group
Año de publicación: 2019
Nº de páginas: 12
Tipo de publicación: Artículo de Revista
DOI: 10.1038/s41598-019-55765-9
ISSN: 2045-2322
Url de la publicación: https://doi.org/10.1038/s41598-019-55765-9
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LOPEZ-TARRUELLA, SARA
ESCUDERO, M. J.
POLLAN, MARINA
MARTÍN, MIGUEL
JARA, CARLOS
BERMEJO, BEGOÑA
GUERRERO-ZOTANO, ANGEL
GARCÍA-SAENZ, JOSÉ
SANTABALLA, ANA
ALBA,EMILIO
ANDRÉS, RAQUEL
MARTÍNEZ, PURIFICACIÓN
CALVO, LOURDES
FERNÁNDEZ, ANTONIO
BATISTA, NORBERTO
LLOMBART-CUSSAC, ANTONIO
ANTÓN, ANTONIO
LAHUERTA, AINHARA
HABA,JUAN DE LA
JOSE MANUEL LOPEZ VEGA
CARRASCO, E.
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