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 Detalle_Publicacion

Tocilizumab in Behçet's disease with refractory ocular and/or neurological involvement: response according to different clinical phenotypes

Abstract: Objectives: Anti-IL6R tocilizumab (TCZ) therapy has proved to be useful in the treatment of refractory ocular and/or neurological involvement of Behçet's disease (BD). However, TCZ efficacy in other BD manifestations remains unclear. In this study we aimed to assess the efficacy of TCZ in the different clinical phenotypes of BD. Methods: This is a multicentre study of BD patients treated with TCZ, due to refractivity to standard systemic treatment. Results: We studied 16 patients (10 men/6 women); mean age 36.5±18.2 years. The main clinical manifestations at TCZ onset were ocular, oral and/or genital ulcers, arthritis, folliculitis and/or neurological involvement. Before TCZ, they had received several conventional and/or biological immunosuppressants, such as methotrexate, cyclosporine, adalimumab or infliximab. TCZ was used in monotherapy or combined with conventional immunosuppressive drugs. The main indications for TCZ prescription were refractory uveitis (n=14) and refractory neurobehçet (n=2). After a median [IQR] follow-up of 20 [9-45] months using TCZ, neurological and ocular domains improved in most cases with complete remission in most patients with uveitis. Articular and peripheral venous manifestations also experienced a favourable evolution. However, oral/genital ulcers, skin lesions and intestinal manifestations followed a torpid course. Conclusions: TCZ is effective in BD with major clinical involvement. However, it does not seem to be effective in oral/genital ulcers or skin lesions.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Clin Exp Rheumatol . Sep-Oct 2021;39 Suppl 132(5):37-42

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2021

Nº de páginas: 6

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Autores/as

BELÉN ATIENZA MATEO

BELTRÁN, EMMA

HERNÁNDEZ-GARFELLA, MARISA

VALLS PASCUAL, ELIA

MARTÍNEZ-COSTA, LUCÍA

ATANES, ANTONIO

MORIANO, CLARA

CORDERO-COMA, MIGUEL

NOLLA, JOAN MIQUEL

CARRASCO CUBERO, CARMEN

SÁNCHEZ MARTÍN, JULIO

CALVO-RÍO, VANESA

DEMETRIO, ROSALÍA

PALMOU-FONTANA, NATALIA

RICARDO BLANCO ALONSO