Buscar

Estamos realizando la búsqueda. Por favor, espere...

 Detalle_Publicacion

Anti-TNF-a therapy in the management of severe neurosarcoidosis: a report of five cases from a single centre and literature review

Abstract: Neurologic manifestations are found in 5-15 % of patients with sarcoidosis. This granulomatous disease may affect any part of the peripheral or the central nervous system, being potentially severe and difficult to treat. Corticosteroids are the cornerstone of therapy in sarcoidosis. However, some patients become resistant or experience side effects to corticosteroids. In these patients, second line therapies including immunosuppressive drugs such as methotrexate, azathioprine, mycophenolate, cyclophosphamide and leflunomide have been used. Anti-TNF-a drugs have been proposed as a therapeutic option for those who are refractory to immunosuppressive drugs or initially in cases of severe sarcoidosis. We report on 5 patients with neurosarcoidosis treated with anti-TNF-a drugs in our center. A literature review of patients with neurosarcoidosis treated with anti-TNF-a drugs was conducted. In our series successful response to anti-TNF-a therapy was achieved. However, the high frequency of relapses following anti-TNF-a discontinuation makes necessary a close follow-up of these patients when the biologic agent is stopped.

Otras publicaciones de la misma revista o congreso con autores/as de la Universidad de Cantabria

 Fuente: Clin Exp Rheumatol. 2014 Mar-Apr;32(2):275-84

Editorial: Clinical and Experimental Rheumatology

 Año de publicación: 2014

Nº de páginas: 10

Tipo de publicación: Artículo de Revista

ISSN: 0392-856X,1593-098X

Proyecto español: RD08/0075 (RIER) ; RD12/0009/0013

Autores/as

LEYRE RIANCHO ZARRABEITIA

MANUEL DELGADO ALVARADO

AGUSTIN OTERINO DURAN

MARIA JOSE SEDANO TOUS

JAVIER RUEDA GOTOR

PÉREZ MARTÍN, INÉS

JOSE ANGEL BERCIANO BLANCO

RICARDO BLANCO ALONSO