Marian Ros is Full Professor and Chair of the Department of Molecular & Cellular Signaling at the IBBTEC. Prof. Ros completed her MD degree with honors at the University of Cantabria in 1982 and received her PhD degree from the same university in 1986. After a postdoctoral stay at the laboratory of John Fallon (University of Wisconsin-Madison, USA) studying the roles of Msx and Hox genes in limb development, she established her own research group devoted to understand the molecular basis of morphogenesis: how the formation of a particular form or structure is genetically and molecularly controlled during vertebrate development. Using the limb as a paradigm, Prof. Ros lab has provided relevant information on the molecules and mechanisms contributing to shape an organ, always with a translational interest towards disease, repair and regeneration. Prof. Ros has always combined research with education teaching Human Anatomy and Embryology, Neuroanatomy and Developmental Biology to undergraduate and graduate students. Prof. Ros is member of the Royal Academy of Medicine of Cantabria and the awardee of the 2013 Prize of Investigation Consejo Social de la Universidad de Cantabria.
A fundamental question in biology is how tissues and organs are built or repaired. Progress in this area is relevant not only for understanding morphogenesis in animal development, but also for potential applications in the fields of tissue engineering and regenerative medicine. During embryonic development, a major challenge is to understand how the formation of a particular structure is genetically and molecularly controlled. This approach also needs to consider that individual cells interact with each other and that the final morphology and function of an organ ultimately result from the coordinated integration of many individual cell events. Using the developing limb as model system, the Ros’ lab has contributed to the molecular characterization of the limb signaling centers and to the understanding of the function of key transcription factors such as the Hox and Hand2 proteins. The group also has made important contributions towards elucidating the mechanisms underlying digit patterning, how the number and identity of the digits is established and controlled during limb development. Our study of the extreme polydactyly phenotypes observed in Gli3;5’Hox compound mutants provided support for a self-organizing Turing-type mechanism underlying digit patterning. Through mouse genetics, and more recently using functional genomic technologies, we have generated and characterized murine models of human congenital malformations to identify the underlying molecular, cellular, and developmental mechanisms. In particular, the implementation of CRISPR/Cas9 genome editing in mice through the electroporation of zygotes has permitted the analysis of the functional contribution of regulatory genomic regions in a very efficient manner. The Ros’ group has contributed more than 90 original papers, several of them in international prestigious journals including Cell, Nature, and Science. The major topics currently under investigation in the lab are:
Spanish Government. Ministry of Science and Innovation
Endika Haro, Florence Petit, Charmaine U. Pira, Conor D. Spady, Lauren A. Ivey, Austin L. Gray, Fabienne Escande, Anne-Sophie Jourdain, Andy Nguyen, Florence Fellmann, Jean-Marc Good, Christine Francannet, S.Manouvrier-Hanu, Marian A. Ros, Kerby C. Oberg
Nat Commun. 2021 Sep 20;12(1):5533. doi: 10.1038/s41467-021-25844-5.
Marc Fernandez-Guerrero, Sofia Zdral, Alejandro Castilla-Ibeas, Lucille Lopez-Delisle, Denis Duboule, Marian A Ros
Dev Dyn. 2021 Jul 12. doi: 10.1002/dvdy.394. Online ahead of print.
Marc Fernandez-Guerrero, Nayuta Yakushiji-Kaminatsui, Lucille Lopez-Delisle, Sofía Zdral, Fabrice Darbellay, Rocío Perez-Gomez, Christopher Chase Bolt, Manuel A. Sanchez-Martin, Denis Duboule, Maria A. Ros
Lara Busby, Cristina Aceituno, Caitlin McQueen, Constance A Rich, Maria A Ros, Matthew Towers
Rocío Pérez-Gómez, Marc Fernández-Guerrero, Víctor Campa, Juan F. Lopez-Gimenez, Alvaro Rada-Iglesias, Maria A. Ros
Maria Félix Bastida, Rocío Pérez-Gómez, Anna Trofka, Jianjian Zhu, Alvaro Rada-Iglesias, Rushikesh Sheth, H. Scott Stadler, Susan Mackem and Marian Ros
Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1090-1096.
Pérez-Gómez R, Haro E, Fernández-Guerrero M, Bastida MF, Ros MA.
Int J Dev Biol. 2018;62(11-12):797-805.
Pickering J, Rich CA, Stainton H, Aceituno C, Chinnaiya K, Saiz-Lopez P, Ros MA, Towers M.
Elife.2018 Sep 3;7. pii: e37429.
Mariani FV, Fernandez-Teran M, Ros MA
Dev Dyn. 2017 Apr;246(4):208-216.
Patricia Saiz-Lopez, Kavitha Chinnaiya, Matthew Towers, Maria A. Ros
Development. 2017 Feb 1;144(3):479-486.
Ruiz P, Martin-Millan M, Gonzalez-Martin MC, Almeida M, González-Macias J, Ros MA.
Sci Rep. 2016 Nov 2;6:36201.
Genes Dev. 2016 May 15;30(10):1135-7.
Saiz-Lopez P, Chinnaiya K, Campa VM, Delgado I, Ros MA, Towers M.
Nat Commun. 2015 Sep 18;6:8108.
Haro E, Delgado I, Junco M, Yamada Y, Mansouri A, Oberg KC, Ros MA
PLoS Genet. 2014 Aug 28;10(8):e1004468.
González-Martín MC, Mallo M, Ros MA.
Dev Biol. 2014 Aug 15;392(2):454-65.
Rushikesh Sheth, Maria Félix Bastida, Marie Kmita, Marian Ros
Dev Dyn. 2014 Jan;243(1):182-91.
Wellik DM, Torres M, Ros MA.
Dev Dyn. 2014 Jan;243(1):1-3.
Fernandez-Teran M, Ros MA, Mariani FV.
Dev Biol. 2013 Sep 15;381(2):341-52
Sheth R, Bastida MF, Kmita M, Ros M.
Sheth R, Grégoire D, Dumouchel A, Scotti M, Pham JM, Nemec S, Bastida MF, Ros MA, Kmita M.
Development. 2013 May; 140(10):2130-8.
Sheth R, Marcon L, Bastida MF, Junco M, Quintana L, Dahn R, Kmita M, Sharpe J, Ros MA.
Science. 2012 Dec 14;338(6113):1476-80.
Garrido-Allepuz C, González-Lamuño D, Ros MA.
PLoS One. 2012;7(9):e44962.
Cooper, K.L., Hu, J. K-H, ten Berge, D., Fernandez-Teran, M., Ros M.A. and Tabin, C.J.
Science. 2011; 332:1083-1086.
Roselló, A., Ros M.A. and Torres, M.
Science. 2011; 332:1086-1088.
Garrido-Allepuz, C, Haro, E, Gonzalez-Lamuño, D, Martinez-Frías, ML, Bertocchini, F and Ros MA.
Disease Models and Mechanisms. 2011; 4:289-299.
Talamillo A, Delgado I, Nakamura T, de-Vega S, Yoshitomi Y, Unda F, Birchmeier W, Yamada Y, Ros M.
Developmental Biology. 2010; 337:363.
Bastida, M.F., Sheth, R. and M.Ros, M.A.
Development. 2009; 136:3779- 3789.
Alvarez-Medina R, Le Dreau G, Ros M, Martí E.
Development. 2009 Oct;136(19):3301-9.
Domínguez-Frutos E, Vendrell V, Alvarez Y, Zelarayan LC, López-Hernández I, Ros M, Schimmang T.
Mech Dev. 2009 Jul 18.
Galloway JL, Delgado I, Ros MA, Tabin CJ.
Nature. 2009 Jul 16;460(7253):400-4
Instituto de Biomedicina y Biotecnología de Cantabria.
PCTCAN - Cl. Albert Einstein, 22